2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone

Base Information

• Chemical Name: 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone
• CAS No.: 193965-96-7
• Molecular Formula: C₂₆H₂₄O₃S
• Molecular Weight: 416.541
• Mol file: 193965-96-7.mol

Synonyms:

Chemical Property of 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone

There total 3 articles about 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrapropylstannane (2176-98-9) + 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 3-bromo-4-methoxyphenyl ketone (193964-26-0) → 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone (193965-96-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 130 ℃; for 4h;

DOI:10.1016/S0960-894X(98)00447-8

Reference yield:

2-(4-methoxyphenyl)benzo[b]thiophene (27884-09-9) → 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone (193965-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / TiCl₄ / 1,2-dichloro-ethane / 3 h

2: Pd(Ph₃P)4 / toluene / 4 h / 130 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; In 1,2-dichloro-ethane; toluene;

DOI:10.1016/S0960-894X(98)00447-8

Reference yield:

3-bromo-4-methoxy-benzoic acid chloride (81324-61-0) → 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxy-3-propylphenyl ketone (193965-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / TiCl₄ / 1,2-dichloro-ethane / 3 h

2: Pd(Ph₃P)4 / toluene / 4 h / 130 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; In 1,2-dichloro-ethane; toluene;

DOI:10.1016/S0960-894X(98)00447-8

upstream raw materials:

tetrapropylstannane

2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 3-bromo-4-methoxyphenyl ketone

2-(4-methoxyphenyl)benzo[b]thiophene

3-bromo-4-methoxy-benzoic acid chloride

Downstream raw materials:

2-(4-Hydroxyphenyl)benzo[b]thiophen-3-yl 4-Hydroxy-3-propylphenyl Ketone

Refernces