S-adenosyl-L-propionine

Base Information

• Chemical Name: S-adenosyl-L-propionine
• CAS No.: 53830-48-1
• Molecular Formula: C₁₇H₂₆N₆O₅S
• Molecular Weight: 426.497
• Mol file: 53830-48-1.mol

Synonyms:

Chemical Property of S-adenosyl-L-propionine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-adenosyl-L-propionine

There total 3 articles about S-adenosyl-L-propionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

S-propyl-D,L-homocysteine (2598-46-1,7021-62-7) + ATP (56-65-5,896506-78-8) → S-adenosyl-L-propionine (53830-48-1)

Guidance literature:

With recombinant S-adenosylmethionine synthase-I₃₁₇A from Bacillus subtilis (strain ATCC 6051); In aq. buffer; at 30 ℃; for 8h; pH=8; Reagent/catalyst; stereoselective reaction; Enzymatic reaction;

DOI:10.1039/c4cc08478k

Reference yield:

(2S)-2-amino-4-(propylsulfanyl)butanoic acid (13073-19-3,7021-62-7) + ATP (56-65-5,896506-78-8) → S-adenosyl-L-propionine (53830-48-1) + 5'-deoxy-5'-(propylthio)adenosine (5135-33-1)

Guidance literature:

With recombinant Homo sapiens methionine adenosyltransferase 2; potassium chloride; magnesium chloride; In aq. buffer; at 37 ℃; for 4h; pH=8; Temperature; Reagent/catalyst; Enzymatic reaction;

DOI:10.1002/anie.201308272

Reference yield:

C8H17NO2S → S-adenosyl-L-propionine (53830-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 6 h / Inert atmosphere; Reflux

2: recombinant S-adenosylmethionine synthase-I₃₁₇A from Bacillus subtilis (strain ATCC 6051) / aq. buffer / 8 h / 30 °C / pH 8 / Enzymatic reaction

With recombinant S-adenosylmethionine synthase-I₃₁₇A from Bacillus subtilis (strain ATCC 6051); sodium hydroxide; In aq. buffer;

DOI:10.1039/c4cc08478k

upstream raw materials:

(2S)-2-amino-4-(propylsulfanyl)butanoic acid

ATP

S-propyl-D,L-homocysteine

Refernces

• 1、 Singh, Shanteri,Zhang, Jianjun,Huber, Tyler D.,Sunkara, Manjula,Hurley, Katherine,Goff, Randal D.,Wang, Guojun,Zhang, Wen,Liu, Chunming,Rohr, Juergen,Van Lanen, Steven G.,Morris, Andrew J.,Thorson, Jon S.. "Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-L-methionine analogues". supporting information. p. 3965 - 3969. Retrieved 2014/05/06.