5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide

Base Information

• Chemical Name: 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide
• CAS No.: 133609-67-3
• Molecular Formula: C₂₀H₂₁NO₂
• Molecular Weight: 307.392
• Mol file: 133609-67-3.mol

Synonyms:

Chemical Property of 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide

There total 3 articles about 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

5,6-Dihydro-2H-pyran-3-carbonsaeurechlorid (133609-62-8) + dibenzylamine (103-49-1) → 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide (133609-67-3)

Guidance literature:

In toluene; at 0 ℃; for 1h;

DOI:10.1007/BF00808961

Reference yield:

5,6-dihydro-2H-pyran-3-carbaldehyde (13417-49-7) → 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide (133609-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 63.7 percent / silver nitrate, sodium hydroxide / aq. ethanol / 1 h / Ambient temperature

2: 87.8 percent / SOCl₂ / benzene / 4 h / 100 °C

3: 24 percent / toluene / 1 h / 0 °C

With sodium hydroxide; thionyl chloride; silver nitrate; In ethanol; toluene; benzene;

DOI:10.1007/BF00808961

Reference yield:

5,6-dihydro-2H-pyran-3-carboxylic acid (100313-48-2) → 5,6-Dihydro-2H-pyran-3-carboxylic acid dibenzylamide (133609-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87.8 percent / SOCl₂ / benzene / 4 h / 100 °C

2: 24 percent / toluene / 1 h / 0 °C

With thionyl chloride; In toluene; benzene;

DOI:10.1007/BF00808961

upstream raw materials:

5,6-Dihydro-2H-pyran-3-carbonsaeurechlorid

dibenzylamine

5,6-dihydro-2H-pyran-3-carbaldehyde

5,6-dihydro-2H-pyran-3-carboxylic acid

Refernces