Technology Process of (3S)-1-{[3-(benzyloxycarbonyl)amino]-2-oxopiperidin-1-yl}urea
There total 8 articles about (3S)-1-{[3-(benzyloxycarbonyl)amino]-2-oxopiperidin-1-yl}urea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1,4-dioxane / 1 h / Reflux
2: water
With
water;
In
1,4-dioxane;
DOI:10.1021/ol3030583
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: tert.-butylnitrite / acetonitrile / 1.5 h / Reflux
3: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / 0 °C
4: sodium tetrahydroborate / methanol / 0.33 h / 0 °C
5: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C
6: hydrazine hydrate / methanol / 24.75 h / 20 °C
7: 1,4-dioxane / 1 h / Reflux
8: water
With
4-methyl-morpholine; sodium tetrahydroborate; tert.-butylnitrite; hydrazine hydrate; carbon tetrabromide; water; sodium hydrogencarbonate; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol3030583
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / methanol / 0.33 h / 0 °C
2: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C
3: hydrazine hydrate / methanol / 24.75 h / 20 °C
4: 1,4-dioxane / 1 h / Reflux
5: water
With
sodium tetrahydroborate; hydrazine hydrate; carbon tetrabromide; water; triphenylphosphine;
In
1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ol3030583