N-methyl-2-(trifluoromethyl)aniline

Base Information

• Chemical Name: N-methyl-2-(trifluoromethyl)aniline
• CAS No.: 14925-10-1
• Molecular Formula: C8H8F3N
• Molecular Weight: 175.153
• Hs Code.: 29214200
• European Community (EC) Number: 624-040-9
• DSSTox Substance ID: DTXSID80375400
• Nikkaji Number: J3.210.619F
• Wikidata: Q82163930
• Mol file: 14925-10-1.mol

Synonyms:N-methyl-2-(trifluoromethyl)aniline;14925-10-1;2-(Methylamino)benzotrifluoride;Benzenamine, N-methyl-2-(trifluoromethyl)-;2-(Trifluoromethyl)-N-methylaniline;2-Trifluoromethyl-N-methylaniline;SCHEMBL880789;2-(methylamino)benzotrifluride;DTXSID80375400;GRZYAMRSOPZXEN-UHFFFAOYSA-N;ANTIPAINHYDROCHLORIDEDIHYDRATE;MFCD00052196;AKOS000252353;TS-02416;Benzenamine,N-methyl-2-(trifluoromethyl)-;2-(Trifluoromethyl)-N-methylaniline, 96%;CS-0313695;FT-0608836;E85420;EN300-1263426;A808869;J-008572

Chemical Property of N-methyl-2-(trifluoromethyl)aniline

Chemical Property:

• Vapor Pressure: 0.411mmHg at 25°C
• Refractive Index: n20/D 1.4880(lit.)
• Boiling Point: 195.8 °C at 760 mmHg
• Flash Point: 72.2 °C
• PSA: 12.03000
• Density: 1.229 g/cm³
• LogP: 2.82010
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 175.06088375
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-2-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNC1=CC=CC=C1C(F)(F)F
• Uses: N-Methyl-2-(trifluoromethyl)aniline

Technology Process of N-methyl-2-(trifluoromethyl)aniline

There total 2 articles about N-methyl-2-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-trifluoromethylphenyl)formamide (91533-85-6) → N-Methyl-2-(trifluoromethyl)aniline (14925-10-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1248/cpb.47.28

Reference yield:

→ N-Methyl-2-(trifluoromethyl)aniline (14925-10-1)

Guidance literature:

N-Methyl-N-tosyl-2-trifluormethyl-anilin, aq.H2SO4, Erwaerm.;

DOI:10.1071/CH9670093

Reference yield: 95.0%

N-Methyl-2-(trifluoromethyl)aniline (14925-10-1) + 4-nitrobenzaldehdye (555-16-8) → 4,4'-((4-nitrophenyl)methylene)bis(N-methyl-2-(trifluoromethyl)aniline)

Guidance literature:

With 3-methyl-1-(4-sulfobutyl)imidazol-3-ium bis((trifluoromethyl)sulfonyl)azanide; In neat (no solvent); at 80 ℃; for 1.5h;

DOI:10.1039/d1ra03724b

upstream raw materials:

N-(2-trifluoromethylphenyl)formamide

Downstream raw materials:

4-[methyl-(2-trifluoromethyl-phenyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

N,N-dimethyl-2-(trifluoromethyl)aniline

Refernces