BKI-1369

Base Information

• Chemical Name: BKI-1369
• CAS No.: 1951431-22-3
• Molecular Formula: C₂₃H₂₇N₇O
• Molecular Weight: 417.514
• Mol file: 1951431-22-3.mol

Synonyms:

Chemical Property of BKI-1369

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

BKI1369 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BKI-1369

There total 14 articles about BKI-1369 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(2-ethoxyquinolin-6-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1363386-80-4) → BKI-1369 (1951431-22-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; Schlenk technique;

DOI:10.1016/j.ejmech.2020.112638

Reference yield:

tert-butyl 4-((4-amino-3-(2-ethoxyquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)piperidine-1-carboxylate → BKI-1369 (1951431-22-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h

2: hydrogenchloride / ethanol

3: sodium methylate / methanol

With hydrogenchloride; sodium methylate; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1021/acs.jmedchem.6b00760

Reference yield:

3-(2-ethoxyquinolin-6-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1363386-80-4) → BKI-1369 (1951431-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol

2: sodium methylate / methanol

With hydrogenchloride; sodium methylate; In methanol; ethanol;

DOI:10.1021/acs.jmedchem.6b00760

upstream raw materials:

formaldehyd

3-(2-ethoxyquinolin-6-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

4-Aminopyrazolo<3,4-d>pyrimidin

4-piperidinemethanol

Refernces

• 1、 Gilles, Philippe,Kashyap, Rudra S.,Freitas, Maria Jo?o,Ceusters, Sam,Van Asch, Koen,Janssens, Anke,De Jonghe, Steven,Persoons, Leentje,Cobbaut, Mathias,Daelemans, Dirk,Van Lint, Johan,Voet, Arnout R.D.,De Borggraeve, Wim M.. "Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors". . . Retrieved 2020/08/25.