NOR-ICARITIN

Base Information

• Chemical Name: NOR-ICARITIN
• CAS No.: 5240-95-9
• Molecular Formula: C₂₀H₂₀O₇
• Molecular Weight: 372.375
• Mol file: 5240-95-9.mol

Synonyms:Flavone,3,4',5,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)- (7CI,8CI); Noricaritin

Chemical Property of NOR-ICARITIN

Chemical Property:

• Boiling Point: 650.2±55.0 °C(Predicted)
• PKA: 6.57±0.40(Predicted)
• PSA: 131.36000
• Density: 1.492
• LogP: 2.98590

Purity/Quality:

≥98% ^*data from raw suppliers

Icaritin(NewProduct) 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NOR-ICARITIN

There total 5 articles about NOR-ICARITIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

8-prenylkaempferol (28610-31-3) → 6,6-dimethyldihydropyran (2,3:7,8)-5,4'-dihydroxyflavonol (28610-34-6) + 8-(3-hydroxy-3-methylbutyl)-5,7,4'-trihydroxyflavonol (5240-95-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 80 ℃; for 5h;

Reference yield:

kaempferol (520-18-3) → 8-(3-hydroxy-3-methylbutyl)-5,7,4'-trihydroxyflavonol (5240-95-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 24 percent / K₂CO₃ / acetone / 8 h / Ambient temperature

2: 14 percent / K₂CO₃ / methanol / 10 h / Ambient temperature

3: 82 percent / Dowex 50 / methanol / 24 h / 40 °C

4: 2 percent / aq. HCl / dioxane / 5 h / 80 °C

With hydrogenchloride; Dowex 50; potassium carbonate; In 1,4-dioxane; methanol; acetone;

Reference yield:

3,4',7-tris-O-methoxymethylkaempferol (143724-66-7) → 8-(3-hydroxy-3-methylbutyl)-5,7,4'-trihydroxyflavonol (5240-95-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 14 percent / K₂CO₃ / methanol / 10 h / Ambient temperature

2: 82 percent / Dowex 50 / methanol / 24 h / 40 °C

3: 2 percent / aq. HCl / dioxane / 5 h / 80 °C

With hydrogenchloride; Dowex 50; potassium carbonate; In 1,4-dioxane; methanol;

upstream raw materials:

8-prenylkaempferol

kaempferol

3,4',7-tris-O-methoxymethylkaempferol

5-hydroxy-8-prenyl-3,4',7-tris-O-methoxymethylkaempferol

Refernces