1-Pyridin-3-ylmethyl-piperazine

Base Information

• Chemical Name: 1-Pyridin-3-ylmethyl-piperazine
• CAS No.: 39244-80-9
• Molecular Formula: C10H15N3
• Molecular Weight: 177.249
• Hs Code.: 29339900
• Mol file: 39244-80-9.mol

Synonyms:1-(3-Pyridylmethyl)piperazine;

Chemical Property of 1-Pyridin-3-ylmethyl-piperazine

Chemical Property:

• Appearance/Colour: pale yellow liquid
• Vapor Pressure: 0.00125mmHg at 25°C
• Melting Point: 177.25oC
• Refractive Index: 1.55
• Boiling Point: 298.62 °C at 760 mmHg
• PKA: 9.04±0.10(Predicted)
• Flash Point: 134.401 °C
• PSA: 28.16000
• Density: 1.074 g/cm³
• LogP: 0.75350
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Pyridin-3-ylmethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

Useful:

Technology Process of 1-Pyridin-3-ylmethyl-piperazine

There total 6 articles about 1-Pyridin-3-ylmethyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + nicotinyl chloride (3099-31-8) → 1-(pyridin-3-ylmethyl)piperazine (39244-80-9)

Guidance literature:

With triethylamine; In ethanol; at 55 ℃; for 12h;

DOI:10.1021/jf902640u

Reference yield:

piperazine (110-85-0) + 3-chloromethylpyridinium chloride (6959-48-4) → 1-(pyridin-3-ylmethyl)piperazine (39244-80-9)

Guidance literature:

With hydrogenchloride; In water; for 16.5h;

Reference yield:

tert-butyl 4-(pyridin-3-ylmethyl)piperazine-1-carboxylate (150812-36-5) → 1-(pyridin-3-ylmethyl)piperazine (39244-80-9)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2011.02.033

upstream raw materials:

piperazine

3-pyridinecarboxaldehyde

3-hydroxymethylpyridin

3-chloromethylpyridinium chloride

Downstream raw materials:

C₂₀H₂₀ClN₅O

(1-(4-chlorobenzyl)-1H-indol-2-yl)(4-(4-(pyridin-3-ylmethyl)piperazine-1-carbonyl)piperidin-1-yl)methanone

C₂₈H₃₈ClN₅O₂

5-bromo-3-nitro-4-(4-(pyridin-3-ylmethyl)piperazin-1-yl)pyridin-2-amine

Refernces

• 1、 Dong, Ming-Xin,Lu, Lu,Li, Haitao,Wang, Xiaohua,Lu, Hong,Jiang, Shibo,Dai, Qiu-Yun. "Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors". scheme or table. p. 3284 - 3286. Retrieved 2012/06/18.
• 2、 Cai, Mingyi,Li, Zhong,Fan, Feng,Huang, Qingchun,Shao, Xusheng,Song, Gonghua. "Design and Synthesis of Novel Insecticides Based on the Serotonergic Ligand 1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine(PAPP)". experimental part. p. 2624 - 2629. Retrieved 2011/07/31.