Lenalidomide

Base Information

• Chemical Name: Lenalidomide
• CAS No.: 879126-98-4
• Molecular Formula: C₁₃H₁₃N₃O₃
• Molecular Weight: 259.265
• Mol file: 879126-98-4.mol

Synonyms:

Chemical Property of Lenalidomide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Lenalidomide

There total 47 articles about Lenalidomide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione (827026-45-9) → Lenalidomide (879126-98-4,879126-99-5,191732-72-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 40 ℃; under 3000.3 Torr; Pressure; Temperature;

Reference yield: 93.0%

methanesulfonate salt of 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione → Lenalidomide (879126-98-4,879126-99-5,191732-72-6)

Guidance literature:

With triethylamine; In isopropyl alcohol; for 1.33333h; Product distribution / selectivity;

Reference yield: 85.0%

dimethyl 2-(4-amino-2,3-dihydro-1-oxo-1H-isoindol-2-yl)glutarate (1198299-50-1) → Lenalidomide (879126-98-4,879126-99-5,191732-72-6)

Guidance literature:

With chloro-trimethyl-silane; sodium methylate; formamide; In acetonitrile; at 5 - 25 ℃; for 6h; Solvent;

upstream raw materials:

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

2-methyl-3-nitro-benzoic acid methyl ester

Cbz-L-Gln

rac-α-aminoglutarimide hydrochloride

Downstream raw materials:

3-(4-amino-1-oxo-1,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione hemihydrate

N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide

N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)benzamide

Refernces

• 1、 -. "Compound for targeted degradation of BTK protein". Paragraph 0458; 0468-0470. . Retrieved 2021/06/22.
• 2、 -. "Method for preparing lenalidomide". Paragraph 0085-0090. . Retrieved 2020/06/09.