C₂₆H₂₅FN₄O₂

Base Information

• Chemical Name: C₂₆H₂₅FN₄O₂
• CAS No.: 1175143-13-1
• Molecular Formula: C₂₆H₂₅FN₄O₂
• Molecular Weight: 444.509
• Mol file: 1175143-13-1.mol

Synonyms:

Chemical Property of C₂₆H₂₅FN₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₅FN₄O₂

There total 10 articles about C₂₆H₂₅FN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H33FN4O4 → C26H25FN4O2 (1175143-13-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2011.06.114

Reference yield:

1H-pyrrolo[3,2-b]pyridine (272-49-1) → C26H25FN4O2 (1175143-13-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 8-quinolinol; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 130 °C

2: bromine; tert-butyl alcohol / water / 20 °C

3: palladium on activated charcoal; hydrogen / ethanol / 20 °C

4: pyridine; trichlorophosphate / dichloromethane / 0 - 20 °C

5: trichlorophosphate / dichloromethane / 100 °C

6: sodium dihydrogenphosphate; sodium chlorite / tert-butyl alcohol / 20 °C

7: 4-methyl-morpholine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

8: sodium hydride / 1-methyl-pyrrolidin-2-one / 20 - 140 °C / Microwave irradiation

9: trifluoroacetic acid / dichloromethane / 20 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; copper(l) iodide; 8-quinolinol; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; palladium on activated charcoal; hydrogen; bromine; sodium hydride; potassium carbonate; trifluoroacetic acid; tert-butyl alcohol; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol; 4: Vilsmeier-Haack reaction;

DOI:10.1016/j.bmcl.2011.06.114

Reference yield:

1-phenyl-1H-pyrrolo[3,2-b]pyridine (514182-79-7) → C26H25FN4O2 (1175143-13-1)

Guidance literature:

Multi-step reaction with 8 steps

1: bromine; tert-butyl alcohol / water / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

3: pyridine; trichlorophosphate / dichloromethane / 0 - 20 °C

4: trichlorophosphate / dichloromethane / 100 °C

5: sodium dihydrogenphosphate; sodium chlorite / tert-butyl alcohol / 20 °C

6: 4-methyl-morpholine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

7: sodium hydride / 1-methyl-pyrrolidin-2-one / 20 - 140 °C / Microwave irradiation

8: trifluoroacetic acid / dichloromethane / 20 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; palladium on activated charcoal; hydrogen; bromine; sodium hydride; trifluoroacetic acid; tert-butyl alcohol; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Vilsmeier-Haack reaction;

DOI:10.1016/j.bmcl.2011.06.114

upstream raw materials:

1H-pyrrolo[3,2-b]pyridine

1-phenyl-1H-pyrrolo[3,2-b]pyridine

1-phenyl-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one

2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde

Refernces