Alamethicin from Trichoderma viride

Base Information

• Chemical Name: Alamethicin from Trichoderma viride
• CAS No.: 27061-78-5
• Molecular Formula: C92H150N22O25
• Molecular Weight: 1964.3078
• Hs Code.: 29419090
• European Community (EC) Number: 608-040-6
• Metabolomics Workbench ID: 144418
• Wikipedia: Alamethicin
• Mol file: 27061-78-5.mol

Synonyms:Alamethicin

Chemical Property of Alamethicin from Trichoderma viride

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 255-270oC
• Flash Point: 87℃
• PSA: 708.13000
• LogP: 3.96740
• Storage Temp.: 2-8°C
• Solubility.: Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 10 mg/ml).
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 22
• Hydrogen Bond Acceptor Count: 25
• Rotatable Bond Count: 53
• Exact Mass: 1963.11424836
• Heavy Atom Count: 139
• Complexity: 4520

Purity/Quality:

98%,99%, ^*data from raw suppliers

Alamethicin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=CC=C2)CO)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C3CCCN3C(=O)C(C)(C)NC(=O)C
• Description: Alamethicin is an antibiotic peptide belonging to a class of membrane active peptides of fungal origin called peptaibols. It contains an unusual amphiphilic amino acid, 2-aminoisobutyric acid, which strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes. Alamethicin is often used to study ion channel assembly, voltage gating, and peptide-membrane interactions. Alamethicin is also widely used as agent to induce various physiological and defense responses in eukaryotic cells including plants.
• Uses: Alamethicin is an acidic linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids”, with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F30 acts an ionopohore, transporting ions through membranes and artificial lipid membranes and forming voltage-dependent ion channels in lipid bilayer membranes. Alamethicin is co-produced with a parallel, neutral, linear peptaibol complex (alamethicin F50). The relative composition of alamethicin is a variable mixture of the acidic and neutral complexes, but reports on alamethacin do not generally specify the ratio of F50 to F30, and comparative data between the complexes is scant. Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides. Alamethicin, Ready Made Solution from Trichoderma viride has been used :In the uridine 5′-diphospho-glucuronosyltransferase activity assay.To determine the Na, K-ATPase activity in permeabilized bovine nonpigmented epithelium cells.In methylcrotonyl-CoA carboxylase activity assay.