(6-methylsulfanylpyrimidin-4-yl)-acetonitrile

Base Information

• Chemical Name: (6-methylsulfanylpyrimidin-4-yl)-acetonitrile
• CAS No.: 1018473-06-7
• Molecular Formula: C₇H₇N₃S
• Molecular Weight: 165.219
• Mol file: 1018473-06-7.mol

Synonyms:

Chemical Property of (6-methylsulfanylpyrimidin-4-yl)-acetonitrile

Chemical Property:

• Boiling Point: 341.3±32.0 °C(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)

Purity/Quality:

2-[6-(Methylsulfanyl)pyrimidin-4-yl]acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-methylsulfanylpyrimidin-4-yl)-acetonitrile

There total 1 articles about (6-methylsulfanylpyrimidin-4-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyano-(6-methylsulfanylpyrimidin-4-yl)-acetic acid methyl ester (1018473-05-6) → (6-methylsulfanylpyrimidin-4-yl)-acetonitrile (1018473-06-7)

Guidance literature:

With sodium chloride; In water; dimethyl sulfoxide; at 160 ℃; for 0.833333h; Microwave irradiation;

Reference yield:

(6-methylsulfanylpyrimidin-4-yl)-acetonitrile (1018473-06-7) → N-(4-methyl-3-(1-methyl-4-(6-methylsulfanylpyrimidin-4-yl)-1H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide (1018473-13-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 2 h / 0 °C

2.1: hydrazine / ethanol / 3 h / 80 °C

3.1: sodium methylate / methanol / 0.5 h

3.2: 20 °C

4.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.75 h / 150 °C / Irradiation

With sodium methylate; caesium carbonate; hydrazine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

(6-methylsulfanylpyrimidin-4-yl)-acetonitrile (1018473-06-7) → N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-1-methyl-1H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide (1018473-14-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 2 h / 0 °C

2.1: hydrazine / ethanol / 3 h / 80 °C

3.1: sodium methylate / methanol / 0.5 h

3.2: 20 °C

4.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.75 h / 150 °C / Irradiation

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

With sodium methylate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; hydrazine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

cyano-(6-methylsulfanylpyrimidin-4-yl)-acetic acid methyl ester

Downstream raw materials:

N-(4-methyl-3-(1-methyl-4-(6-methylsulfanylpyrimidin-4-yl)-1H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-1-methyl-1H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

N-(4-methyl-3-(1-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-1H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS". Page/Page column 70. . Retrieved 2008/06/13.