JWH 181

Base Information

• Chemical Name: JWH 181
• CAS No.: 824960-03-4
• Molecular Formula: C₂₈H₃₁NO
• Molecular Weight: 397.56
• Mol file: 824960-03-4.mol

Synonyms:

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of JWH 181

Chemical Property:

• Boiling Point: 562.1±38.0 °C(Predicted)
• Density: 1.06

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of JWH 181

There total 4 articles about JWH 181 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

→ JWH-181 (824960-03-4)

Guidance literature:

Reference yield:

N,N-diphenyl-4-propyl-1-naphthalenecarboxamide → JWH-181 (824960-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

2: thionyl chloride / 0.25 h / Heating

3: 0.11 g / EtAlCl₂ / toluene; hexane / 96 h

With potassium hydroxide; thionyl chloride; ethylaluminum dichloride; In hexane; toluene; diethylene glycol; 3: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

Reference yield:

4-propyl-1-naphthoic acid (107777-22-0) → JWH-181 (824960-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.25 h / Heating

2: 0.11 g / EtAlCl₂ / toluene; hexane / 96 h

With thionyl chloride; ethylaluminum dichloride; In hexane; toluene; 2: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

upstream raw materials:

2-methyl-1-pentylindole

4-propyl-1-naphthoic acid

Refernces

• 1、 -. "CB2-selective cannabinoid analogues". Page 24-25. . Retrieved 2010/02/10.