C₁₅H₂₂N₂O₃

Base Information

• Chemical Name: C₁₅H₂₂N₂O₃
• CAS No.: 1416134-47-8
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.351
• Mol file: 1416134-47-8.mol

Synonyms:

Chemical Property of C₁₅H₂₂N₂O₃

Chemical Property:

• Boiling Point: 391.2±52.0 °C(Predicted)
• PKA: 7.47±0.10(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₂N₂O₃

There total 41 articles about C₁₅H₂₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

ethyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate oxalic acid salt (1416134-48-9) → (2S,5R)?5?[(benzyloxy)amino]piperidine?2?carboxylate (1416134-47-8)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 - 25 ℃; for 2h;

Reference yield: 96.8%

(x)C2H2O4*C15H22N2O3 → (2S,5R)?5?[(benzyloxy)amino]piperidine?2?carboxylate (1416134-47-8)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 - 25 ℃; for 2h;

Reference yield: 95.0%

(2S,5R)-5-(benzyloxyamino)piperidin-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester (1463501-46-3) → (2S,5R)?5?[(benzyloxy)amino]piperidine?2?carboxylate (1416134-47-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate

(S)-ethyl N-tert-butoxycarbonylpyroglutamate

(S)-ethyl 2-(((tert-butoxy)carbonyl)amino)-6-diazo-5-oxohexanoate

O-benzylhydoxylamine hydrochloride

Downstream raw materials:

(2R,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid

Refernces

• 1、 -. "Preparation method of 5R-benzyloxyaminopiperidine-2S-formate". Paragraph 0045-0050. . Retrieved 2021/09/29.
• 2、 Davies, David T.,Leiris, Simon,Zalacain, Magdalena,Sprynski, Nicolas,Castandet, Jér?me,Bousquet, Justine,Lozano, Clarisse,Llanos, Agustina,Alibaud, Laethitia,Vasa, Srinivas,Pattipati, Ramesh,Valige, Ravindar,Kummari, Bhaskar,Pothukanuri, Srinivasu,De Piano, Cyntia,Morrissey, Ian,Holden, Kirsty,Warn, Peter,Marcoccia, Francesca,Benvenuti, Manuela,Pozzi, Cecilia,Tassone, Giusy,Mangani, Stefano,Docquier, Jean-Denis,Pallin, David,Elliot, Richard,Lemonnier, Marc,Everett, Martin. "Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii". . p. 15802 - 15820. Retrieved 2021/01/09.