9-Amino-(9-deoxy)epi-dihydroquinine trihydrochloride

Base Information

• Chemical Name: 9-Amino-(9-deoxy)epi-dihydroquinine trihydrochloride
• CAS No.: 931098-91-8
• Molecular Formula: C₂₀H₂₇N₃O*3ClH
• Molecular Weight: 434.837
• Hs Code.: 29339900
• Mol file: 931098-91-8.mol

Synonyms:

Chemical Property of 9-Amino-(9-deoxy)epi-dihydroquinine trihydrochloride

Chemical Property:

• Melting Point: 214-215 °C (decomp)(Solv: ethyl acetate (141-78-6); methanol (67-56-1))

Purity/Quality:

98%,99%, ^*data from raw suppliers

(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine trihydrochloride 90% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-Amino-(9-deoxy)epi-dihydroquinine trihydrochloride

There total 7 articles about 9-Amino-(9-deoxy)epi-dihydroquinine trihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

epi-dihydroquinine (522-66-7,1435-55-8,14645-32-0,23495-98-9,26666-96-6,47342-32-5,47342-33-6,51049-33-3,51049-34-4,66182-83-0,66182-84-1,51743-68-1) → 9-epi-9-amino-9-deoxy-dihydroquinidine trihydrochloride (931098-91-8)

Guidance literature:

epi-dihydroquinine; With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine; In tetrahydrofuran; at 0 - 45 ℃; for 6h; Inert atmosphere;

With triphenylphosphine; In tetrahydrofuran; water; at 45 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm300648b

Reference yield:

C20H25N5O → 9-amino-9-deoxydihydroquinine trihydrochloride (931098-91-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/ol0628006

Reference yield:

4-[(S)-Azido-((1S,2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-methoxy-quinoline → 9-epi-9-amino-9-deoxydihydroquinine trihydrochloride (931098-91-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/ol0628006

upstream raw materials:

dihydroquinidine

epi-dihydroquinine

epi-dihydroquinine

dihydroquinine

Refernces

• 1、 McCooey, Seamus H.,Connon, Stephen J.. "Readily accessible 9-epi-amino cinchona alkaloid derivatives promote efficient, highly enantioselective additions of aldehydes and ketones to nitroolefins". . p. 599 - 602. Retrieved 2008/02/02.