8-amino-3,6-dichloroquinoline

Base Information

• Chemical Name: 8-amino-3,6-dichloroquinoline
• CAS No.: 158117-56-7
• Molecular Formula: C₉H₆Cl₂N₂
• Molecular Weight: 213.066
• Mol file: 158117-56-7.mol

Synonyms:

Chemical Property of 8-amino-3,6-dichloroquinoline

Chemical Property:

• Boiling Point: 372.5±37.0 °C(Predicted)
• Density: 1.490±0.06 g/cm3(Predicted)

Purity/Quality:

98.5% ^*data from raw suppliers

3,6-Dichloroquinolin-8-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-amino-3,6-dichloroquinoline

There total 4 articles about 8-amino-3,6-dichloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,6-dichloro-8-nitroquinoline (158117-54-5) → 8-amino-3,6-dichloroquinoline (158117-56-7)

Guidance literature:

With hydrogenchloride; iron; In ethanol; for 3h; Heating;

DOI:10.1007/BF01277632

Reference yield:

8-nitroquinoline (607-35-2) → 8-amino-3,6-dichloroquinoline (158117-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chlorosuccinimide / acetic acid / 336 h / Ambient temperature

2: 95 percent / Fe powder, conc. HCl / aq. ethanol / 3 h / Heating

With hydrogenchloride; N-chloro-succinimide; iron; In ethanol; acetic acid;

DOI:10.1007/BF01277632

Reference yield:

4-Chloro-2-nitroaniline (89-63-4) → 8-amino-3,6-dichloroquinoline (158117-56-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄, m-O₂NC₆H₄SO₃Na / H₂O / 4 h / Heating

2: N-chlorosuccinimide / acetic acid / 2 h / Heating

3: 95 percent / Fe powder, conc. HCl / aq. ethanol / 3 h / Heating

With hydrogenchloride; N-chloro-succinimide; sulfuric acid; iron; sodium 3-nitrobenzenesulfonate; In ethanol; water; acetic acid;

DOI:10.1007/BF01277632

upstream raw materials:

3,6-dichloro-8-nitroquinoline

8-nitroquinoline

4-Chloro-2-nitroaniline

6-chloro-8-nitroquinoline

Refernces