CPD1548

Base Information

• Chemical Name: CPD1548
• CAS No.: 1851373-36-8
• Molecular Formula: C₂₄H₂₅N₃O₂
• Molecular Weight: 387.481
• Mol file: 1851373-36-8.mol

Synonyms:

Chemical Property of CPD1548

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-PyridinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-Pyridinecarboxylic Acid is also known as a KDM4 inhibitor exhibiting antiproliferative effects in cancer models.

Technology Process of CPD1548

There total 10 articles about CPD1548 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 3-({[(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylate → 3-({[(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid (1851373-36-8)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00220

Reference yield: 56.0%

methyl 3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylate → 3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid (1851373-36-8)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 53.0%

→ 3-({[(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid (1851373-36-8)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

upstream raw materials:

methyl 3-fluoropyridine-4-carboxylate

6-bromo-3,4-dihydro-2H-naphthalen-1-one

Refernces

• 1、 Chen, Young K.,Bonaldi, Tiziana,Cuomo, Alessandro,Del Rosario, Joselyn R.,Hosfield, David J.,Kanouni, Toufike,Kao, Shih-Chu,Lai, Chon,Lobo, Neethan A.,Matuszkiewicz, Jennifer,McGeehan, Andrew,O'Connell, Shawn M.,Shi, Lihong,Stafford, Jeffrey A.,Stansfield, Ryan K.,Veal, James M.,Weiss, Michael S.,Yuen, Natalie Y.,Wallace, Michael B.. "Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models". . p. 869 - 874. Retrieved 2017/08/16.