Boc-Cys(Trt)-Gly-OCH₂Ph

Base Information

• Chemical Name: Boc-Cys(Trt)-Gly-OCH₂Ph
• CAS No.: 67952-04-9
• Molecular Formula: C₃₆H₃₈N₂O₅S
• Molecular Weight: 610.774
• Mol file: 67952-04-9.mol

Synonyms:

Chemical Property of Boc-Cys(Trt)-Gly-OCH₂Ph

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Cys(Trt)-Gly-OCH₂Ph

There total 1 articles about Boc-Cys(Trt)-Gly-OCH₂Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine (21947-98-8,87494-13-1) + glycine benzyl ester p-toluenesulfonic acid salt (1738-76-7) → Boc-Cys(Trt)-Gly-OCH2Ph (67952-04-9)

Guidance literature:

Multistep reaction; (i) ClCO₂iBu, N-methylmorpholine, DMF, (ii) /BRN= 3600116/;

DOI:10.1021/jo00419a046

Reference yield:

Boc-Cys(Trt)-Gly-OCH2Ph (67952-04-9) + trifluoroacetic acid (76-05-1) → ((R)-2-Amino-3-mercapto-propionylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid (160876-46-0)

Guidance literature:

With ethanethiol; Yield given. Multistep reaction; 1.) 0 deg C, 2.) 0 deg C, 700 mbar, 20 min; r.t., 6 h;

Reference yield:

C16H21NO6S2 (67952-00-5) + Boc-Cys(Trt)-Gly-OCH2Ph (67952-04-9) → Boc-Cys(Cys-Boc)-Gly-OCH2Ph

Guidance literature:

Multistep reaction; (i) H₂S, Hg(OAc)2, AcOEt, MeOH, (ii) /BRN= 2310627/, CHCl₃, MeOH;

DOI:10.1021/jo00419a046

upstream raw materials:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine

glycine benzyl ester p-toluenesulfonic acid salt

Downstream raw materials:

((R)-2-Amino-3-mercapto-propionylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

Refernces

• 1、 Albrich, Hans,Vahrenkamp, Heinrich. "Zinc Complexes of Amino Acids and Peptides, 3 . - Zinc Complexes of Peptides with N-terminal Cysteine". . p. 1223 - 1234. Retrieved 2007/10/02.