2-Methoxy-4-phenylphenol

Base Information

• Chemical Name: 2-Methoxy-4-phenylphenol
• CAS No.: 37055-79-1
• Molecular Formula: C13H12 O2
• Molecular Weight: 200.237
• Mol file: 37055-79-1.mol

Synonyms:Guaiacol,4-phenyl- (6CI); 3-Methoxy-4-hydroxybiphenyl; 4-Hydroxy-3-methoxybiphenyl

Chemical Property of 2-Methoxy-4-phenylphenol

Chemical Property:

• Vapor Pressure: 0.000119mmHg at 25°C
• Boiling Point: 325.7°C at 760 mmHg
• Flash Point: 171.6°C
• Density: 1.13g/cm³

Purity/Quality:

95% ^*data from raw suppliers

2-Methoxy-4-phenylphenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-4-phenylphenol

There total 15 articles about 2-Methoxy-4-phenylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyloxy-3-methoxybiphenyl (125101-83-9) → 4-hydroxy-3-methoxybiphenyl (37055-79-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jm060358r

Reference yield: 83.0%

4-bromoguaiacol (7368-78-7) + phenylboronic acid (98-80-6) → 4-hydroxy-3-methoxybiphenyl (37055-79-1)

Guidance literature:

With potassium hydroxide; palladium on activated charcoal; In water; at 120 ℃; for 0.25h; microwave irradiation;

DOI:10.1016/j.tetlet.2006.04.027

Reference yield: 81.0%

4-Hydroxy-2-methoxy-4-phenyl-cyclohexa-2,5-dienone (110391-82-7) → 4-hydroxy-3-methoxybiphenyl (37055-79-1)

Guidance literature:

With copper; acetic acid; zinc; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jo00231a022

upstream raw materials:

3,4-dimethoxy-1,1'-biphenyl

4-benzyloxy-3-methoxybiphenyl

4-Hydroxy-2-methoxy-4-phenyl-cyclohexa-2,5-dienone

4-bromoguaiacol

Downstream raw materials:

C₁₄H₁₄O₃

Refernces

• 1、 Freundlich, Joel S.,Landis, Howard E.. "An expeditious aqueous Suzuki-Miyaura method for the arylation of bromophenols". . p. 4275 - 4279. Retrieved 2007/10/03.
• 2、 Ozaki,Oshio,Ohsuga,Kaburagi,Sung,Kim. "A new entry to the synthesis of 1,2-benzenediol congeners". . p. 1132 - 1136. Retrieved 2007/10/02.