1-Naphthalenecarboxylicacid, 4-ethyl-

Base Information

• Chemical Name: 1-Naphthalenecarboxylicacid, 4-ethyl-
• CAS No.: 91902-58-8
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• Hs Code.: 2916399090
• Mol file: 91902-58-8.mol

Synonyms:1-Naphthoicacid, 4-ethyl- (6CI,7CI);NSC 408421;

Chemical Property of 1-Naphthalenecarboxylicacid, 4-ethyl-

Chemical Property:

• Vapor Pressure: 1.98E-06mmHg at 25°C
• Refractive Index: 1.636
• Boiling Point: 379.3 °C at 760 mmHg
• Flash Point: 173.2 °C
• PSA: 37.30000
• Density: 1.185g/cm³
• LogP: 3.10040
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

4-Ethyl-1-naphthoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Ethyl-1-naphthoic acid is used in the preparation of antimalarial compounds. It also shows some plant-growth activity.

Technology Process of 1-Naphthalenecarboxylicacid, 4-ethyl-

There total 9 articles about 1-Naphthalenecarboxylicacid, 4-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N-diphenyl-4-ethyl-1-naphthalenecarboxamide (824430-38-8) → 4-ethyl-1-naphthalenecarboxylic acid (91902-58-8)

Guidance literature:

With potassium hydroxide; In diethylene glycol; for 8h; Heating;

DOI:10.1016/j.bmc.2004.09.050

Reference yield: 86.0%

1-ethyl-1,4-dihydronaphthalene-1,4-dicarboxylic acid → 4-ethyl-1-naphthalenecarboxylic acid (91902-58-8)

Guidance literature:

With chlorosulfonic acid; In chloroform; at 0 ℃;

DOI:10.1002/ejoc.201200823

Reference yield:

1-bromo-4-ethylnaphthalene (67668-17-1) → 4-ethyl-1-naphthalenecarboxylic acid (91902-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CuCN

With CuCN;

DOI:10.1021/ja01167a017

upstream raw materials:

carbamic chloride

1-ethylnapthelene

(4-ethylnaphthalen-1-yl)methanol

N,N-diphenyl-4-ethyl-1-naphthalenecarboxamide

Downstream raw materials:

(4-ethylnaphthalen-1-yl)methanol

1-ethyl-4-chloromethyl-naphthalene

5-(4-ethyl-1-naphthoylamino)-1,3,4-thiadiazole-2-sulfonamide

Refernces

• 1、 Huffman, John W.,Zengin, Gulay,Wu, Ming-Jung,Lu, Jianzhong,Hynd, George,Bushell, Kristen,Thompson, Alicia L.S.,Bushell, Simon,Tartal, Cindy,Hurst, Dow P.,Reggio, Patricia H.,Selley, Dana E.,Cassidy, Michael P.,Wiley, Jenny L.,Martin, Billy R.. "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists". . p. 89 - 112. Retrieved 2007/10/03.