N-(4,6-dimethylpyrimidin-2-yl)glycine

Base Information

• Chemical Name: N-(4,6-dimethylpyrimidin-2-yl)glycine
• CAS No.: 55684-37-2
• Molecular Formula: C8H11N3O2
• Molecular Weight: 181.1918
• Mol file: 55684-37-2.mol

Synonyms:N-(4,6-Dimethylpyrimidin-2-yl)glycine;NSC 222816;

Chemical Property of N-(4,6-dimethylpyrimidin-2-yl)glycine

Chemical Property:

• Vapor Pressure: 3.9E-07mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 400.6 °C at 760 mmHg
• Flash Point: 196 °C
• Density: 1.303 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4,6-dimethylpyrimidin-2-yl)glycine

There total 1 articles about N-(4,6-dimethylpyrimidin-2-yl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-(4,6-dimethyl-pyrimidin-2-yl)-glycine (55684-37-2)

Guidance literature:

Acetylaceton, Guanidinoessigsaeure;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + N-(4,6-dimethyl-pyrimidin-2-yl)-glycine (55684-37-2) → (3aR,6aS)-2-benzyl-5-(4,6-dimethylpyrimidin-2-yl)tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione

Guidance literature:

With para-dichlorobenzene; In ⁽²⁾H₈-toluene; at 250 ℃; for 1h; Concentration; Sealed tube; Microwave irradiation; Inert atmosphere;

Reference yield:

N-(4,6-dimethyl-pyrimidin-2-yl)-glycine (55684-37-2) → ((3aR,6aS)-5-(4,6-dimethylpyrimidin-2- yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:

Multi-step reaction with 3 steps

1.1: ⁽²⁾H₈-toluene / 1 h / 250 °C / Sealed tube; Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 4 h / 0 - 50 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Heating

3.1: sodium carbonate / toluene; water / 30 - 70 °C / Inert atmosphere

With borane-THF; sodium carbonate; In tetrahydrofuran; ⁽²⁾H₈-toluene; water; toluene;