Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate

Base Information

• Chemical Name: Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate
• CAS No.: 14961-34-3
• Molecular Formula: C13H16O4
• Molecular Weight: 236.268
• Mol file: 14961-34-3.mol

Synonyms:Homophthalsaeure-diaethylester;Diethyl homophthalate;(2-ethoxycarbonyl-phenyl)-acetic acid ethyl ester;(2-Aethoxycarbonyl-phenyl)-essigsaeure-aethylester;ethyl 2-(ethoxycarbonyl)phenylacetate;2-Ethoxycarbonylmethyl-benzoic acid ethyl ester;

Chemical Property of Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate

Chemical Property:

• Melting Point: 20 - 22 °C
• Boiling Point: 164-169 °C(Press: 19 Torr)
• PSA: 52.60000
• Density: 1.093 g/cm3(Temp: 25 °C)
• LogP: 1.96890

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(2-ethoxy-2-oxoethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate

There total 12 articles about Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethanol (64-17-5) + Homophthalic acid (89-51-0) → diethyl homophthalate (14961-34-3)

Guidance literature:

With thionyl chloride; at 75 ℃; for 24h;

Reference yield: 71.0%

2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + diethyl malonate (105-53-3) → diethyl homophthalate (14961-34-3)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1039/b505392g

Reference yield: 51.0%

2-iodophenyltrifluoromethanesulfonic acid (129112-26-1) + diethyl malonate (105-53-3) → diethyl homophthalate (14961-34-3)

Guidance literature:

With triethylsilane; cesium fluoride; In tetrahydrofuran; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00279

upstream raw materials:

ethanol

Homophthalic acid

2-cyanomethylbenzoic acid

hydrogenchloride

Downstream raw materials:

2-(2-carboxy-phenyl)-3-phenyl-acrylic acid

1-oxo-1H-isochromene-4-carboxylic acid

o-Ethoxycarbonyl-α-nitrotoluol

2-[Ethoxycarbonyl-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl]-benzoic acid

Refernces

• 1、 Cottet, F.,Cottier, L.,Descotes, G.. "New Syntheses of Isochromene". . p. 497 - 498. Retrieved 1987.
• 2、 Minoshima, Mai,Uchida, Keisuke,Nakamura, Yu,Hosoya, Takamitsu,Yoshida, Suguru. "Acylalkylation of Arynes Generated from o-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride". supporting information. p. 1868 - 1873. Retrieved 2021/03/08.
• 3、 -. "2-PHENYL BENZOYLAMIDES". Page/Page column 49-50. . Retrieved 2011/12/04.