5-(Dimethylamino)-5-oxopentanoic acid

Base Information

• Chemical Name: 5-(Dimethylamino)-5-oxopentanoic acid
• CAS No.: 151675-59-1
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.18300
• Hs Code.: 2924199090
• Mol file: 151675-59-1.mol

Synonyms:dimethylaminooxopentanoicacid;Pentanoic acid,5-(dimethylamino)-5-oxo;5-dimethylamino-5-oxopentanoic acid;4-(dimethylaminocarbonyl)butanoic acid;4-(dimethylcarbamoyl)butanoic acid;

Chemical Property of 5-(Dimethylamino)-5-oxopentanoic acid

Chemical Property:

• PSA: 57.61000
• LogP: 0.32950

Purity/Quality:

98%min ^*data from raw suppliers

5-?(Dimethylamino)?-?5-?oxopentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-?(Dimethylamino)?-?5-?oxopentanoic Acid acts as a reagent in the synthesis of leukotriene B4 analogs for improved receptor binding activity.

Technology Process of 5-(Dimethylamino)-5-oxopentanoic acid

There total 1 articles about 5-(Dimethylamino)-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

Iodoacetic acid (64-69-7) + N,N-Dimethylacrylamide (2680-03-7,68761-83-1) → 4-(dimethylaminocarbonyl)butanoic acid (151675-59-1)

Guidance literature:

With sodium tetrahydroborate; azobisisobutyronitrile; tributyltin chloride; In ethanol; for 7h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81929-3

Reference yield: 84.0%

N-(p-chlorobenzylidene)-p-toluenesulfonamide (3157-65-1) + 4-(dimethylaminocarbonyl)butanoic acid (151675-59-1) → C21H25ClN2O5S

Guidance literature:

4-(dimethylaminocarbonyl)butanoic acid; With dimethylsulfide borane complex; In dichloromethane; toluene; for 1h; Inert atmosphere;

N-(p-chlorobenzylidene)-p-toluenesulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; toluene; at 20 ℃; for 3h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jacs.5b04175

Reference yield:

methanol (67-56-1) + 4-(dimethylaminocarbonyl)butanoic acid (151675-59-1) → N,N-Dimethylglutaramid-methylester (14471-87-5)

Guidance literature:

With thionyl chloride; In dichloromethane;

DOI:10.1021/jo051887q

upstream raw materials:

Iodoacetic acid

N,N-Dimethylacrylamide

Downstream raw materials:

ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-hydroxyphenyl}propanoate

N,N-Dimethylglutaramid-methylester

Refernces