(1H-indol-3-ylmethyl)propanedioic acid

Base Information

• Chemical Name: (1H-indol-3-ylmethyl)propanedioic acid
• CAS No.: 4361-05-1
• Molecular Formula: C12H11 N O4
• Molecular Weight: 233.224
• Mol file: 4361-05-1.mol

Synonyms:Malonicacid, (indol-3-ylmethyl)- (6CI,7CI,8CI); Propanedioic acid,(1H-indol-3-ylmethyl)- (9CI); 1H-Indole-3-propanoic acid, a-carboxy-; NSC 61166

Chemical Property of (1H-indol-3-ylmethyl)propanedioic acid

Chemical Property:

• Vapor Pressure: 1.67E-11mmHg at 25°C
• Boiling Point: 516.8°C at 760 mmHg
• Flash Point: 266.3°C
• Density: 1.482g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1H-indol-3-ylmethyl)propanedioic acid

There total 6 articles about (1H-indol-3-ylmethyl)propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-[(1H-indol-3-yl)methyl]malonate (10184-98-2) → indol-3-ylmethyl-malonic acid (4361-05-1)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01230a012

Reference yield:

(3-indolylmethyl)trimethylammonium iodide (5457-31-8) → indol-3-ylmethyl-malonic acid (4361-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dibutyl ether

2: aqueous NaOH

With sodium hydroxide; dibutyl ether;

DOI:10.1021/ja01230a012

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → indol-3-ylmethyl-malonic acid (4361-05-1)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine; acetic acid; benzene

2: platinum; ethanol / Hydrogenation

3: aqueous KOH

With piperidine; potassium hydroxide; ethanol; acetic acid; platinum; benzene;

DOI:10.1021/jo01090a631

upstream raw materials:

3-(Dimethylaminomethyl)indole

methanetricarboxylic acid triethyl ester

diethyl 2-[(1H-indol-3-yl)methyl]malonate

(3-indolylmethyl)trimethylammonium iodide

Downstream raw materials:

Indole-3-propionic acid