Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, sodium salt

Base Information

• Chemical Name: Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, sodium salt
• CAS No.: 16654-89-0
• Molecular Formula: C15H24O.Na
• Molecular Weight: 242.337
• Mol file: 16654-89-0.mol

Synonyms:

Chemical Property of Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, sodium salt

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, sodium salt

There total 1 articles about Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-di-tert-butyl-4-methyl-phenol (128-37-0) → sodium 2,6-di-tert-butyl-4-methylphenoxide (16654-89-0)

Guidance literature:

With sodium hydride; In diethyl ether; at 20 ℃; for 6h; Inert atmosphere; Glovebox;

DOI:10.1002/chem.202101617

Reference yield: 85.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + ytterbium(III) chloride (10361-91-8) + sodium 2,6-di-tert-butyl-4-methylphenoxide (16654-89-0) → Yb(OC6H2(C(CH3)3)2CH3)(Cl)2(C4H8O)3 (204399-99-5)

Guidance literature:

In tetrahydrofuran; byproducts: NaCl; Ar-atmosphere; stirring (room temp., 72 h); centrifugation, evapn. (vac.); elem. anal.;

Reference yield: 81.2%

ytterbium(III) chloride (10361-91-8) + (2-((2,6-diisopropylphenyl)amino)-4-((2,6-diisopropylphenyl)imino)-pent-2-ene) lithium salt + sodium 2,6-di-tert-butyl-4-methylphenoxide (16654-89-0) → (N,N'-diisopropylphenyl-2,4-pentanediimine)YbCl(THF)(2,6-di-tert-butyl-4-methylphenoxo) (573984-25-5)

Guidance literature:

In tetrahydrofuran; hexane; toluene; under Ar atm. using Schlenk techniques; anhyd. YbCl3 in THF slowly addedto soln. of β-diketiminate in toluene-hexane at room temp.; THF so ln. of 2,6-t-Bu-4-Me-C6H2ONa slowly added; mixt. stirred at room temp. for 48 h; ppt. removed by centrifugation; THF removed (vac.); toluene added; ppt. removed by centrifugation; crystals were obtained from concd. toluene soln. at -20°C for 4 ds; elem. anal.;

DOI:10.1021/om030136g

upstream raw materials:

2,6-di-tert-butyl-4-methyl-phenol

Downstream raw materials:

2,6-Di-tert-butyl-4-methylphenol trimethylsilyl ether

2,6-di-tert-butyl-4-methylphenoxy radical

Trichloro-(2,6-di-tert-butyl-4-methyl-phenoxy)-silane

2,6-Di-t-butyl-4-methylphenoxydimethylchlorosilane

Refernces

• 1、 Semeniuchenko, Volodymyr,Ovens, Jeffrey S.,Braje, Wilfried M.,Organ, Michael G.. "NaBHT Generated in Situ from BHT and NaO tBu: Crystallographic Characterization and Applications in Buchwald-Hartwig Amination". supporting information. p. 3276 - 3290. Retrieved 2021/10/12.
• 2、 Sammes, Peter G.,Thetford, Dean,Voyle, Martyn. "A NOVEL, SIMPLE METHOD FOR THE PREPARATION OF HINDERED DIPHENYL ETHERS". . p. 3229 - 3232. Retrieved 2007/10/02.