Benzoic acid 2-thienyl ester

Base Information

• Chemical Name: Benzoic acid 2-thienyl ester
• CAS No.: 16693-98-4
• Molecular Formula: C11H8O2S
• Molecular Weight: 204.249
• Mol file: 16693-98-4.mol

Synonyms:2-thienyl benzoate;Benzoesaeure-[2]thienylester;benzoic acid-[2]thienyl ester;

Chemical Property of Benzoic acid 2-thienyl ester

Chemical Property:

• Melting Point: 43-44 °C
• Boiling Point: 323.2±15.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.258±0.06 g/cm3(Predicted)
• LogP: 2.96730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid 2-thienyl ester

There total 4 articles about Benzoic acid 2-thienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,5-dihydro-2H-2-oxothiophene (3354-32-3) + benzoyl chloride (98-88-4) → thiophen-2-yl benzoate (16693-98-4)

Guidance literature:

With triethylamine; at 50 ℃; for 3h;

DOI:10.1002/jhet.5570350409

Reference yield: 14.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + dibenzoyl peroxide (94-36-0) → thiophen-2-yl benzoate (16693-98-4)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 60h; regioselective reaction; Inert atmosphere; Irradiation;

DOI:10.1002/ejoc.201201093

Reference yield:

thiophen-2-ol (17236-58-7) + benzoyl chloride (98-88-4) → thiophen-2-yl benzoate (16693-98-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01168a049

upstream raw materials:

thiophen-2-ol

benzoyl chloride

2,5-dihydro-2H-2-oxothiophene

thiophene

Downstream raw materials:

benzoic acid benzyl ester

benzoic acid phenyl ester

Refernces

• 1、 Lee, Chang Kiu,Yu, Ji Sook,Kim, Sun Hee. "Synthesis of Five-membered 2-Heteroaryl 2-Heteroaromatic Carboxylates and Attempted Cyclization to Bisheteroaryl[2,3-b:3′2′-d]pyran-2-one". . p. 835 - 841. Retrieved 2007/10/03.