ethylalpha-bromodiethylacetate

Base Information

• Chemical Name: ethylalpha-bromodiethylacetate
• CAS No.: 6937-28-6
• Molecular Formula: C8H15BrO2
• Molecular Weight: 223.11
• Mol file: 6937-28-6.mol

Synonyms:Ethylalpha-bromodiethylacetate;Ethyl 2-bromo-2-ethylbutanoate;

Chemical Property of ethylalpha-bromodiethylacetate

Chemical Property:

• Vapor Pressure: 0.355mmHg at 25°C
• Refractive Index: 1.46
• Boiling Point: 198.7 °C at 760 mmHg
• Flash Point: 82.4 °C
• PSA: 26.30000
• Density: 1.258 g/cm³
• LogP: 2.50320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

α-BromodiethylaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: ethylalpha-bromodiethylacetate is an α-bromo tertiary ester used as a reagent in in organic synthesis.

Technology Process of ethylalpha-bromodiethylacetate

There total 1 articles about ethylalpha-bromodiethylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 2-ethyl-2-bromo-butyric acid (5456-23-5) → ethyl 2-bromo-2-ethylbutanoate (6937-28-6)

Guidance literature:

With hydrogenchloride;

Reference yield: 93.0%

1-methyl-4-isopropenylbenzene (1195-32-0) + ethyl 2-bromo-2-ethylbutanoate (6937-28-6) → C18H26O2

Guidance literature:

With copper(l) iodide; benzyl tri-n-butylammonium bromide; tris[(2-pyridylmethyl)amine]; triethylamine; In toluene; at 100 ℃; for 20h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol502953w

Reference yield: 75.0%

ethyl 2-bromo-2-ethylbutanoate (6937-28-6) + benzaldehyde (100-52-7) → ethyl 2-benzoyl-2-ethylbutanoate (116773-05-8)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2021.132212

upstream raw materials:

ethanol

2-ethyl-2-bromo-butyric acid

Downstream raw materials:

2-bromo-2-ethylbutanamide

2-ethyl-2-(α-hydroxy-benzyl)-butyric acid ethyl ester

2-Ethyl-2-(1-hydroxy-cyclohexyl)-butyric acid ethyl ester

ethyl 2-benzoyl-2-ethylbutanoate

Refernces