2,4-Difluoro-5-Methoxybenzaldehyde

Base Information

• Chemical Name: 2,4-Difluoro-5-Methoxybenzaldehyde
• CAS No.: 177034-25-2
• Molecular Formula: C8H6F2O2
• Molecular Weight: 172.131
• Hs Code.: 2914500090
• Mol file: 177034-25-2.mol

Synonyms:Benzaldehyde,2,4-difluoro-5-methoxy;

Chemical Property of 2,4-Difluoro-5-Methoxybenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 1.78590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2,4-Difluoro-5-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Difluoro-5-Methoxybenzaldehyde

There total 3 articles about 2,4-Difluoro-5-Methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Dichloromethyl methyl ether (4885-02-3) + 2,4-difluoro-1-methoxybenzene (452-10-8) → 2,4-difluoro-5-methoxybenzaldehyde (177034-25-2)

Guidance literature:

Dichloromethyl methyl ether; 2,4-difluoro-1-methoxybenzene; With titanium tetrachloride; at 0 - 20 ℃; for 0.166667h;

With water; In dichloromethane;

Reference yield: 62.0%

4-fluoro-3-methoxybenzaldehyde (128495-46-5) → 2,4-difluoro-5-methoxybenzaldehyde (177034-25-2)

Guidance literature:

With 4-aminobenzene-1,3-disulfonic acid; palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; at 110 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1021/jacs.8b00048

Reference yield:

→ 2,4-difluoro-5-methoxybenzaldehyde (177034-25-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 0 ℃; for 1.5h;

upstream raw materials:

Dichloromethyl methyl ether

2,4-difluoro-1-methoxybenzene

4-fluoro-3-methoxybenzaldehyde

Downstream raw materials:

2-(2,4-difluoro-5-methoxyphenyl)-2-hydroxyacetonitrile

Refernces

• 1、 -. "TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF". Paragraph 00139; 00145. . Retrieved 2018/04/11.