2-Amino-6-(1,2-dihydroxypropyl)-4,7(1H,8H)-pteridinedione

Base Information

• Chemical Name: 2-Amino-6-(1,2-dihydroxypropyl)-4,7(1H,8H)-pteridinedione
• CAS No.: 490-58-4
• Molecular Formula: C₉H₁₁N₅O₄
• Molecular Weight: 253.217
• Mol file: 490-58-4.mol

Synonyms:1,2-Propanediol,1-(2-amino-4,7-dihydroxy-6-pteridinyl)- (7CI,8CI); Ichthyopterin (6CI); Fluorescyanine

Chemical Property of 2-Amino-6-(1,2-dihydroxypropyl)-4,7(1H,8H)-pteridinedione

Chemical Property:

• Vapor Pressure: 9.29E-24mmHg at 25°C
• Boiling Point: 752°C at 760 mmHg
• Flash Point: 408.6°C
• PSA: 157.98000
• Density: 2.03g/cm³
• LogP: -1.41600

Purity/Quality:

ICHTHYOPTERIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-6-(1,2-dihydroxypropyl)-4,7(1H,8H)-pteridinedione

There total 4 articles about 2-Amino-6-(1,2-dihydroxypropyl)-4,7(1H,8H)-pteridinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,4-diketopentanoate (615-79-2) → 2-amino-6-(1,2-dihydroxy-propyl)-3H,8H-pteridine-4,7-dione (490-58-4,18503-56-5,23259-60-1,141783-04-2,141783-05-3,141783-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous methanol; morpholine

2: SeO₂; acetic acid

3: NaBH₄; aqueous Na₂CO₃

With morpholine; methanol; sodium tetrahydroborate; selenium(IV) oxide; sodium carbonate; acetic acid;

Reference yield:

2-amino-6-pyruvoyl-3H,8H-pteridine-4,7-dione (98590-10-4) → 2-amino-6-(1,2-dihydroxy-propyl)-3H,8H-pteridine-4,7-dione (490-58-4,18503-56-5,23259-60-1,141783-04-2,141783-05-3,141783-06-4)

Guidance literature:

With sodium tetrahydroborate; sodium carbonate; optically inactive 2-amino-6-<1,2-dihydroxy-propyl>-3H,8H-pteridine-4,7-dione;

Reference yield:

6-(1-acetoxy-2-oxo-propyl)-2-amino-3H,8H-pteridine-4,7-dione (99845-08-6) → 2-amino-6-(1,2-dihydroxy-propyl)-3H,8H-pteridine-4,7-dione (490-58-4,18503-56-5,23259-60-1,141783-04-2,141783-05-3,141783-06-4)

Guidance literature:

With sodium tetrahydroborate; sodium carbonate; optically inactive 2-amino-6-<1,2-dihydroxy-propyl>-3H,8H-pteridine-4,7-dione;

upstream raw materials:

2-amino-6-pyruvoyl-3H,8H-pteridine-4,7-dione

6-(1-acetoxy-2-oxo-propyl)-2-amino-3H,8H-pteridine-4,7-dione

6-acetonyl-2-amino-3H,8H-pteridine-4,7-dione

ethyl 2,4-diketopentanoate

Downstream raw materials:

2-amino-4,7-dioxo-3,4,7,8-tetrahydro-pteridine-6-carbaldehyde