1-(2-Ethoxyethyl)piperazine

Base Information

• Chemical Name: 1-(2-Ethoxyethyl)piperazine
• CAS No.: 13484-38-3
• Molecular Formula: C8H18N2O
• Molecular Weight: 158.24
• Hs Code.: 2933599090
• European Community (EC) Number: 623-350-1
• DSSTox Substance ID: DTXSID80370415
• Wikidata: Q72471597
• Mol file: 13484-38-3.mol

Synonyms:1-(2-Ethoxyethyl)piperazine;13484-38-3;1-(2-ethoxy-ethyl)-piperazine;1-(2-Ethoxyethyl)-piperazine;MFCD01320899;Piperazine,1-(2-ethoxyethyl)-;4-(2-ethoxyethyl)piperazine;SCHEMBL92631;1-(2-ethoxy-ethyl)piperazine;4-(2-Ethoxy-ethyl)-piperazine;DTXSID80370415;TXQLUKMSYDOGDH-UHFFFAOYSA-N;1-(2-Ethoxyethyl)piperazine, 97%;AKOS009158923;PS-5838;FT-0636901;EN300-70951;A26638;F2169-0416;Z385435684

Chemical Property of 1-(2-Ethoxyethyl)piperazine

Chemical Property:

• Appearance/Colour: clear colorless to slightly yellow liquid
• Melting Point: 115-117℃
• Refractive Index: n20/D 1.4690(lit.)
• Boiling Point: 220.273 °C at 760 mmHg
• Flash Point: 87.019 °C
• PSA: 24.50000
• Density: 0.928 g/cm³
• LogP: 0.19480
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 158.141913202
• Heavy Atom Count: 11
• Complexity: 92.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Ethoxyethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 16-26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOCCN1CCNCC1

Technology Process of 1-(2-Ethoxyethyl)piperazine

There total 5 articles about 1-(2-Ethoxyethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-ethoxycarbonyl-4-(2-ethoxyethyl)piperazine (88708-35-4) → 1-(2-ethoxyethyl)piperazine (13484-38-3)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1135/cccc19832395

Reference yield: 14.0%

piperazine (110-85-0) + 2-Bromoethyl ethyl ether (592-55-2) → 1-(2-ethoxyethyl)piperazine (13484-38-3)

Guidance literature:

With triethylamine; In ethanol; for 19h; Heating;

DOI:10.1248/cpb.41.148

Reference yield:

piperazine-1-carbaldehyde (7755-92-2) + 2-Bromoethyl ethyl ether (592-55-2) → 1-(2-ethoxyethyl)piperazine (13484-38-3)

Guidance literature:

upstream raw materials:

1-(2-ethoxy-ethyl)-4-phenyl-piperazine

piperazine

2-Bromoethyl ethyl ether

1-ethoxycarbonyl-4-(2-ethoxyethyl)piperazine

Downstream raw materials:

2-Bromo-4-(2-chlorophenyl)-9-<4-(2-ethoxyethyl)piperazino>-6H-thieno<3,2-f>-1,2,4-triazolo<4,3-a>-1,4-diazepine

8-chloro-6-(2-chlorophenyl)-1-<4-(2-ethoxyethyl)piperazino>-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

8-chloro-6-(2-chlorophenyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

1-(2-ethoxyethyl)-4-ethylpiperazine

Refernces

• 1、 Yamane,Hashizume,Yamashita,Konishi,Hosoe,Hidaka,Watanabe,Kawaharada,Yamamoto,Kuze. "Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives". . p. 148 - 155. Retrieved 2007/10/02.