Technology Process of Unii-R9bkh74ftv
There total 9 articles about Unii-R9bkh74ftv which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: NaBH3CN; AcOH / 1 h / 5 °C
2.1: CHCl3 / 1 h / 20 °C
3.1: 83 percent / Br2; AcOH
4.1: 93 percent / HNO3; H2SO4 / acetic acid / 6 h / 5 °C
5.1: 69 percent / aq. NaOH / methanol / 2 h / Heating
6.1: NaH / dimethylformamide / 0.5 h / 20 °C
6.2: dimethylformamide / 10 h / 20 °C
7.1: H2 / 5 percent Pd/C / benzene / 10 h / 30 °C / 2280 Torr
8.1: Et3N / CHCl3 / 1 h / 20 °C
With
sodium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; sodium hydride; sodium cyanoborohydride; acetic acid; triethylamine;
palladium on activated charcoal;
In
methanol; chloroform; acetic acid; N,N-dimethyl-formamide; benzene;
1.1: Hydrogenation / 2.1: Acetylation / 3.1: Bromination / 4.1: Nitration / 5.1: Deacetylation / 6.1: Metallation / 6.2: Alkylation / 7.1: Reduction / 8.1: Acylation;
DOI:10.1248/cpb.48.817
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: CHCl3 / 1 h / 20 °C
2.1: 83 percent / Br2; AcOH
3.1: 93 percent / HNO3; H2SO4 / acetic acid / 6 h / 5 °C
4.1: 69 percent / aq. NaOH / methanol / 2 h / Heating
5.1: NaH / dimethylformamide / 0.5 h / 20 °C
5.2: dimethylformamide / 10 h / 20 °C
6.1: H2 / 5 percent Pd/C / benzene / 10 h / 30 °C / 2280 Torr
7.1: Et3N / CHCl3 / 1 h / 20 °C
With
sodium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; sodium hydride; acetic acid; triethylamine;
palladium on activated charcoal;
In
methanol; chloroform; acetic acid; N,N-dimethyl-formamide; benzene;
1.1: Acetylation / 2.1: Bromination / 3.1: Nitration / 4.1: Deacetylation / 5.1: Metallation / 5.2: Alkylation / 6.1: Reduction / 7.1: Acylation;
DOI:10.1248/cpb.48.817
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 83 percent / Br2; AcOH
2.1: 93 percent / HNO3; H2SO4 / acetic acid / 6 h / 5 °C
3.1: 69 percent / aq. NaOH / methanol / 2 h / Heating
4.1: NaH / dimethylformamide / 0.5 h / 20 °C
4.2: dimethylformamide / 10 h / 20 °C
5.1: H2 / 5 percent Pd/C / benzene / 10 h / 30 °C / 2280 Torr
6.1: Et3N / CHCl3 / 1 h / 20 °C
With
sodium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; sodium hydride; acetic acid; triethylamine;
palladium on activated charcoal;
In
methanol; chloroform; acetic acid; N,N-dimethyl-formamide; benzene;
1.1: Bromination / 2.1: Nitration / 3.1: Deacetylation / 4.1: Metallation / 4.2: Alkylation / 5.1: Reduction / 6.1: Acylation;
DOI:10.1248/cpb.48.817