N-(2-Hydroxyethyl)benzamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)benzamide
• CAS No.: 18838-10-3
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 18838-10-3.mol

Synonyms:2-benzoylaminoethanol;N-benzoylethanolamine;

Chemical Property of N-(2-Hydroxyethyl)benzamide

Chemical Property:

• Melting Point: 52 - 55°C
• PSA: 52.82000
• LogP: 0.98350
• Storage Temp.: -20°C, Inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-hydroxyethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Hydroxyethyl)benzamide

There total 88 articles about N-(2-Hydroxyethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethanolamine (141-43-5) + 6-methyl-2,4-pyrimidine-diyl dibenzoate (155632-06-7) → 6-Methyluracil (626-48-2) + N-(2-hydroxyethyl)-benzamide (18838-10-3)

Guidance literature:

In dichloromethane; for 0.25h; Heating;

DOI:10.1016/S0040-4020(01)87037-X

Reference yield: 99.0%

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-benzamide (18838-10-3)

Guidance literature:

With 14C₂H₂F₃O^(1-)*6C₄H₈O*La₂Na₈⁽¹⁴⁺⁾; at 80 ℃; for 6h; Inert atmosphere;

Reference yield: 99.0%

9-benzoyl-9H-carbazole (19264-68-7) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-benzamide (18838-10-3)

Guidance literature:

In tetrahydrofuran; at 30 ℃; for 24h; chemoselective reaction;

DOI:10.1246/bcsj.20200116

upstream raw materials:

2-benzamidoethyl benzoate

2-azidoethanol

benzaldehyde

benzoyl chloride

Downstream raw materials:

N-(2-chloro-ethyl)-benzamide

3-benzoyl-2-diethylamino-[1,3,2]oxazaphospholidine

monoethanolamine benzoate

2-phenyl-1,3-oxazoline

Refernces

• 1、 Belen'kii, L. I.,Cheskis, M. A.. "SYNTHESIS AND SOME ELECTROPHILIC SUBSTITUTION REACTIONS OF 2-PHENYLOXAZOLE". . p. 713 - 716. Retrieved 1984.
• 2、 Juenge,Gurka,Kreienbaum. "Analysis of drug contamination from parabens in theophylline olamine". . p. 589 - 593. Retrieved 1981.
• 3、 Masui, Masaichiro,Ozaki, Shigeko. "ELECTROCHEMICAL ACYLATION AND ALKYLAMINOCARBONYLATION OF AMINES AND ALCOHOLS". . p. 2867 - 2870. Retrieved 1982.
• 4、 Rodriguez Del Rey, Freddy O.,Floreancig, Paul E.. "Synthesis of Nitrogen-Containing Heterocycles through Catalytic Dehydrative Cyclization Reactions". supporting information. p. 150 - 154. Retrieved 2021/01/09.
• 5、 Boughaba, Sara,Aouf, Zineb,Zerrouki, Rachida,Aouf, Nour Eddine. "N,O-Benzyl Protection of Structurally Varied Amines and Phenols Using Wells-Dawson Heteropolyacid Catalyst". . p. 301 - 310. Retrieved 2021/05/24.