KIRENOL

Base Information

• Chemical Name: KIRENOL
• CAS No.: 52659-56-0
• Molecular Formula: C20H34O4
• Molecular Weight: 338.48
• Hs Code.: 29399990
• Mol file: 52659-56-0.mol

Synonyms:Kirel

Chemical Property of KIRENOL

Chemical Property:

• Melting Point: 197.0 to 201.0 °C
• Refractive Index: 1.57
• Boiling Point: 516.902 °C at 760 mmHg
• PKA: 14.06±0.20(Predicted)
• Flash Point: 233.593 °C
• PSA: 80.92000
• Density: 1.177 g/cm³
• LogP: 2.25190
• Storage Temp.: -20°C Freezer
• Solubility.: Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Kirenol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC50 value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.
• Uses: Kirenol is a pharmaceutical agent that induces apoptosis in human chronic myeloid leukemia cells.