METHYL 2-PHENYLCYCLOPROPANECARBOXYLATE

Base Information

• Chemical Name: METHYL 2-PHENYLCYCLOPROPANECARBOXYLATE
• CAS No.: 20030-70-0
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2916399090
• Mol file: 20030-70-0.mol

Synonyms:cis-1-Phenyl-3-methoxycarbonylcyclopropane;trans-1-Phenyl-cyclopropan-2-carbonsaeure-methylester;methyl trans-2-phenylcyclopropane-1-carboxylate;Methyl 2-phenylcyclopropanecarboxylate;(1S,2S)-2-phenylcyclopropanecarboxylic acid methyl ester;Cyclopropanecarboxylic acid,2-phenyl-,methyl ester;methyl (1S,2S)-(+)-2-phenylcyclopropanecarboxylate;

Chemical Property of METHYL 2-PHENYLCYCLOPROPANECARBOXYLATE

Chemical Property:

• PSA: 26.30000
• Density: 1.136
• LogP: 1.96310

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-phenylcyclopropanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-PHENYLCYCLOPROPANECARBOXYLATE

There total 75 articles about METHYL 2-PHENYLCYCLOPROPANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+)-trans-2,2-dibromo-3-phenylcyclopropanecarboxylic acid methyl ester (1205000-67-4) → (1R,2R)-2-phenylcyclopropanecarboxylic acid methyl ester (5682-61-1,5861-31-4,10488-03-6,16205-72-4,20030-70-0,67528-62-5,67528-63-6,67528-69-2,67528-70-5)

Guidance literature:

With tri-n-butyl-tin hydride; In benzene; at 20 - 55 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.10.077

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (1S,2R)-2-phenylcyclopropanecarboxylic acid (23020-18-0) → (1S,2R)-2-phenylcyclopropanecarboxylic acid methyl ester (5682-61-1,5861-31-4,10488-03-6,16205-72-4,20030-70-0,67528-62-5,67528-63-6,67528-69-2,67528-70-5)

Guidance literature:

at -10 - -5 ℃;

DOI:10.1002/hlca.19860690821

Reference yield: 97.0%

2-phenyl-cyclopropanecarboxylic acid (5685-38-1) → methyl 2-phenylcyclopropane-1-carboxylate (20030-70-0)

Guidance literature:

With sulfuric acid; In methanol;

upstream raw materials:

diazomethane

(1S,2S)-2-phenylcyclopropane-1-carboxylic acid

(1S)-2-phenylcyclopropane-1-carboxylic acid

styrene

Downstream raw materials:

(1S,2S)-trans-1-(hydroxymethyl)-2-phenylcyclopropane

(1S,2R)-2-phenylcyclopropylmethanol

(1R,2R)-1-hydroxymethyl-2-phenylcyclopropane

methyl 3-(benzyl)propanoate

Refernces

• 1、 Endres, Andreas,Maas, Gerhard. "A fluorous phase approach to rhodium-catalyzed carbenoid reactions with diazoacetates". . p. 6365 - 6368. Retrieved 1999.
• 2、 Nanjo, Takeshi,Takemoto, Yoshiji,Yumura, Taichi. "Boronic Acid-Mediated Photocatalysis Enables the Intramolecular Hydroacylation of Olefins Using Carboxylic Acids". supporting information. . Retrieved 2022/03/31.
• 3、 Cheng, Xionglve,Jiang, Gangzhong,Li, Xingxing,Tao, Suyan,Wan, Xiaobing,Zhao, Yanwei,Zheng, Yonggao. "Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite". supporting information. p. 2713 - 2718. Retrieved 2021/06/25.