2,3,6-Trimethylanisole

Base Information

• Chemical Name: 2,3,6-Trimethylanisole
• CAS No.: 21573-36-4
• Molecular Formula: C10H14O
• Molecular Weight: 150.221
• Hs Code.: 2909309090
• Mol file: 21573-36-4.mol

Synonyms:1-methoxy-2,3,6-trimethylbenzene;2,3,6-Trimethylanisol;Benzene,2-methoxy-1,3,4-trimethyl;2,3,6-Trimethylanisole;Anisole,2,3,6-trimethyl;

Chemical Property of 2,3,6-Trimethylanisole

Chemical Property:

• PSA: 9.23000
• LogP: 2.62040

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,6-Trimethylanisole

There total 8 articles about 2,3,6-Trimethylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

2,3,6-trimethylphenol (2416-94-6) + acetic acid (64-19-7,77671-22-8) → 2,3,5-Trimethyl-1,4-benzoquinone (935-92-2) + Duroquinone (527-17-3,70128-24-4) + pentamethylphenol (2819-86-5) + 1-methoxy-2,3,6-trimethylbenzene (21573-36-4) + 2,3,5-trimethyl-1,4-hydroquinone diacetate (7479-28-9) + 2,3,6-trimethylphenyl acetate (62687-45-0)

Guidance literature:

With peracetic acid; at 50 ℃; for 0.25h; Product distribution; Kinetics; Thermodynamic data;

Reference yield: 99.0%

2,3,6-trimethylphenol (2416-94-6) + carbonic acid dimethyl ester (616-38-6) → 1-methoxy-2,3,6-trimethylbenzene (21573-36-4)

Guidance literature:

With dimanganese decacarbonyl; at 180 ℃; for 1h; Reagent/catalyst;

DOI:10.1134/S1070428015030070

Reference yield: 92.0%

2,3,6-trimethylphenol (2416-94-6) + methyl iodide (74-88-4) → 1-methoxy-2,3,6-trimethylbenzene (21573-36-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

upstream raw materials:

peracetic acid

2,3,6-trimethylphenol

acetic acid

methyl iodide

Downstream raw materials:

1-iodo-4-methoxy-2,3,5-trimethylbenzene

2-methoxy-1,3,4-trimethyl-5-nitrobenzene

Refernces

• 1、 Rinkel, Jan,Babczyk, Alexander,Wang, Tao,Stadler, Marc,Dickschat, Jeroen S.. "Volatiles from the hypoxylaceous fungi Hypoxylon griseobrunneum and Hypoxylon macrocarpum". . p. 2974 - 2990. Retrieved 2019/01/05.
• 2、 Khusnutdinov,Shchadneva,Mayakova, Yu. Yu.. "Methylation of phenol and its derivatives with dimethyl carbonate in the presence of Mn2(CO)10, W(CO)6, and Co2(CO)8". . p. 330 - 334. Retrieved 2015/05/04.