2-(Methylamino)benzenethiol

Base Information

• Chemical Name: 2-(Methylamino)benzenethiol
• CAS No.: 21749-63-3
• Molecular Formula: C7H9NS
• Molecular Weight: 139.221
• Hs Code.: 2930909090
• Mol file: 21749-63-3.mol

Synonyms:N-methyl-2-aminothiophenole;2-methylamino-benzenethiol;2-methyl-aminothiophene;

Chemical Property of 2-(Methylamino)benzenethiol

Chemical Property:

• Boiling Point: 142-143 °C(Press: 30 Torr)
• PKA: 10.30±0.10(Predicted)
• PSA: 50.83000
• Density: 1.145±0.06 g/cm3(Predicted)
• LogP: 2.09000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Methylamino)benzenethiol

There total 14 articles about 2-(Methylamino)benzenethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-methylbenzothiazole-2-thione (2254-94-6) → 2-(methylamino)benzenethiol (21749-63-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 14h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.0c00567

Reference yield: 91.0%

di-(o-formamidophenyl) disulphide (40445-33-8) → 2-(methylamino)benzenethiol (21749-63-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1002/anie.200701270

Reference yield: 69.0%

2,3-dihydro-benzothiazole (4433-52-7) → 2-(methylamino)benzenethiol (21749-63-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; 1) 12 h, 20 deg C 2) 3 h, reflux;

upstream raw materials:

2-Imino-3-methylbenzothiazolin

3-methyl-(3H)benzothiazolone

3-methylbenzothiazole-2-thione

di-(o-formamidophenyl) disulphide

Downstream raw materials:

2,5-bis(benzo[d]thiazol-2-yl)thiophene

3-methyl-2-phenoxy-4',4',5',5'-tetramethyl-2,3-dihydro-2λ⁵-spiro[benzo[1,3,2]thiazaphosphole-2,2'-[1,3,2]dioxaphospholane]

N-methyl-2-S-benzylthioaniline

4-methyl-1,4-benzothiazin-3(4H)-one

Refernces

• 1、 Dhakshinamoorthy, Amarajothi,Alvaro, Mercedes,Garcia, Hermenegildo. "Metal organic frameworks as heterogeneous catalysts for the selective N-methylation of aromatic primary amines with dimethyl carbonate". experimental part. p. 19 - 25. Retrieved 2010/08/20.
• 2、 Selva, Maurizio,Tundo, Pietro,Foccardi, Tommaso. "Mono-N-methylation of functionalized anilines with alkyl methyl carbonates over NaY faujasites. 4. Kinetics and selectivity". . p. 2476 - 2485. Retrieved 2007/10/03.