2-(Benzyloxy)benzyl chloride

Base Information

• Chemical Name: 2-(Benzyloxy)benzyl chloride
• CAS No.: 23915-08-4
• Molecular Formula: C14H13ClO
• Molecular Weight: 232.71
• Hs Code.: 2909309090
• Mol file: 23915-08-4.mol

Synonyms:2-(Benzyloxy)benzylchloride;Benzene,1-(chloromethyl)-2-(phenylmethoxy);o-benzyloxy benzyl chloride;

Chemical Property of 2-(Benzyloxy)benzyl chloride

Chemical Property:

• Boiling Point: 344.5±22.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.152±0.06 g/cm3(Predicted)
• LogP: 4.00440
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

1-(Benzyloxy)-2-(chloromethyl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Benzyloxy)benzyl chloride

There total 11 articles about 2-(Benzyloxy)benzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

salicylic alcohol (90-01-7) → 2-benzyloxybenzyl chloride (23915-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / potassium carbonate / acetone / 4 h / Heating

2: 92 percent / thionyl chloride / CH₂Cl₂ / 3 h / 0 °C

With thionyl chloride; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.bmc.2005.10.051

Reference yield:

benzyl bromide (100-39-0) → 2-benzyloxybenzyl chloride (23915-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / potassium carbonate / acetone / 4 h / Heating

2: 92 percent / thionyl chloride / CH₂Cl₂ / 3 h / 0 °C

With thionyl chloride; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.bmc.2005.10.051

Reference yield:

benzyl bromide (100-39-0) → 2-benzyloxybenzyl chloride (23915-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaOH / H₂O; methanol

2: 60 percent / thionyl chloride / CH₂Cl₂ / 18 h / Heating

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane; water;

DOI:10.1211/0022357021778592

upstream raw materials:

salicylic alcohol

benzyl bromide

2-methyl-benzyl alcohol

2-(phenylmethoxy)benzaldehyde

Downstream raw materials:

1-Benzyloxy-2-phenylsulfanylmethyl-benzene

1-(2-benzyloxybenzyl)cycloheptanol

2-(2-benzyloxybenzyl)-1-cyclohexylethane-1-ol

2-(phenylmethoxy)benzaldehyde

Refernces

• 1、 Lee, Jeewoo,Lee, Ju-Hyun,Kim, Su Yeon,Perry, Nicholas A.,Lewin, Nancy E.,Ayres, Jolene A.,Blumberg, Peter M.. "2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands". . p. 2022 - 2031. Retrieved 2007/10/03.
• 2、 Lisowski, Vincent,Enguehard, Cecile,Lancelot, Jean-Charles,Caignard, Daniel-Henri,Lambel, Stephanie,Leonce, Stephane,Pierre, Alain,Atassi, Ghanem,Renard, Pierre,Rault, Sylvain. "Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents". . p. 2205 - 2208. Retrieved 2007/10/03.