AKOS BBS-00003969

Base Information

• Chemical Name: AKOS BBS-00003969
• CAS No.: 4225-92-7
• Molecular Formula: C11H13 Br O
• Molecular Weight: 241.128
• Hs Code.: 2914700090
• Mol file: 4225-92-7.mol

Synonyms:Acetophenone,2-bromo-2',4',6'-trimethyl- (6CI,7CI,8CI); 2,4,6-Trimethylphenacyl bromide;2-Bromo-2',4',6'-trimethylacetophenone; NSC 861

Chemical Property of AKOS BBS-00003969

Chemical Property:

• Vapor Pressure: 0.00132mmHg at 25°C
• Boiling Point: 297.8°C at 760 mmHg
• Flash Point: 53.6°C
• PSA: 17.07000
• Density: 1.317g/cm³
• LogP: 3.18940
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

2-Bromo-1-mesitylethanone 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BBS-00003969

There total 6 articles about AKOS BBS-00003969 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4,6-Trimethylacetophenone (1667-01-2,51885-97-3) → 2-bromo-1-(2,4,6-trimethylphenyl)ethanone (4225-92-7)

Guidance literature:

Reference yield: 94.0%

2-bromoacetyl chloride (22118-09-8) + 1,3,5-trimethyl-benzene (108-67-8) → 2-bromo-1-(2,4,6-trimethylphenyl)ethanone (4225-92-7)

Guidance literature:

With aluminum (III) chloride; at 0 - 20 ℃; for 15h;

DOI:10.1002/chem.201702209

Reference yield: 15.0%

2,4,6-Trimethylacetophenone (1667-01-2,51885-97-3) → 2-bromo-1-(2,4,6-trimethylphenyl)ethanone (4225-92-7) + 3-bromo-2,4,6-trimethylacetophenone (408511-50-2)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid;

DOI:10.1039/c39890001548

upstream raw materials:

2,4,6-Trimethylacetophenone

2-Bromoacetyl bromide

1,3,5-trimethyl-benzene

2-bromoacetyl chloride

Downstream raw materials:

N-(4-mesitylthiazol-2-yl)-2-(pyridin-4-yl)acetamide

4-cyano-N-(4-mesitylthiazol-2-yl)benzamide

4-[(4-mesitylthiazol-2-yl)carbamoyl]pyridine 1-oxide

4-[(4-mesitylthiazol-2-yl)carbamoyl]pyridine 1-oxide

Refernces

• 1、 Yamamoto, Takahiro,Togo, Hideo. "One-Pot Preparation of Aromatic Amides, 4-Arylthiazoles, and 4-Arylimidazoles from Arenes". . p. 4187 - 4196. Retrieved 2018/08/21.
• 2、 Ran, Kai,Gao, Chao,Deng, Hongxia,Lei, Qian,You, Xinyu,Wang, Ningyu,Shi, Yaojie,Liu, Zhihao,Wei, Wei,Peng, Cuiting,Xiong, Lu,Xiao, Kunjie,Yu, Luoting. "Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents". supporting information. p. 3669 - 3674. Retrieved 2016/07/21.