(11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl octadecanoate

Base Information

• Chemical Name: (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl octadecanoate
• CAS No.: 81047-65-6
• Molecular Formula: C39H64 O6
• Molecular Weight: 628.9219
• Mol file: 81047-65-6.mol

Synonyms:Cortisol,21-stearate (6CI); Hydrocortisone stearate; NSC 14933

Chemical Property of (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl octadecanoate

Chemical Property:

• Vapor Pressure: 3.4E-24mmHg at 25°C
• Boiling Point: 723.9°C at 760 mmHg
• Flash Point: 212°C
• Density: 1.09g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl octadecanoate

There total 2 articles about (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl octadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

HYDROCORTISONE (50-23-7) + heptadecanoic acid (506-12-7) → 21-octadecanoyloxy-11β,17α-dihydroxypregn-4-en-3,20-dione (81047-65-6)

Guidance literature:

With Candida antarctica lipase B; In ethanol; toluene; at 110 ℃; regioselective reaction;

DOI:10.1016/j.steroids.2009.07.010

Reference yield: 65.0%

HYDROCORTISONE (50-23-7) + methyl margarate (1731-92-6) → 21-octadecanoyloxy-11β,17α-dihydroxypregn-4-en-3,20-dione (81047-65-6)

Guidance literature:

With Candida antarctica lipase B; In toluene; at 110 ℃; regioselective reaction;

DOI:10.1016/j.steroids.2009.07.010

upstream raw materials:

HYDROCORTISONE

heptadecanoic acid

methyl margarate

Refernces