2-CHLOROPHENOXYACETONITRILE

Base Information

• Chemical Name: 2-CHLOROPHENOXYACETONITRILE
• CAS No.: 43111-31-5
• Molecular Formula: C8H6ClNO
• Molecular Weight: 167.595
• Hs Code.: 2926909090
• Mol file: 43111-31-5.mol

Synonyms:Acetonitrile,(2-chlorophenoxy)- (9CI);Acetonitrile, (o-chlorophenoxy)- (6CI,7CI);(o-Chlorophenoxy)acetonitrile;2-Chlorophenoxyacetonitrile;

Chemical Property of 2-CHLOROPHENOXYACETONITRILE

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 0.00472mmHg at 25°C
• Refractive Index: 1.5425-1.5445
• Boiling Point: 276.7 °C at 760 mmHg
• Flash Point: 121.2 °C
• PSA: 33.02000
• Density: 1.238 g/cm³
• LogP: 2.24238

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Chlorophenoxy)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROPHENOXYACETONITRILE

There total 3 articles about 2-CHLOROPHENOXYACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-monochlorophenol (95-57-8) + cyanomethyl bromide (590-17-0) → 2-(2-chlorophenoxy)acetonitrile (43111-31-5)

Guidance literature:

With potassium carbonate; In acetone; at 20 - 60 ℃; for 22h;

Reference yield:

2-monochlorophenol (95-57-8) + chloroacetonitrile (107-14-2) → 2-(2-chlorophenoxy)acetonitrile (43111-31-5)

Guidance literature:

With potassium carbonate; butanone; potassium iodide;

Reference yield:

→ 2-(2-chlorophenoxy)acetonitrile (43111-31-5)

Guidance literature:

upstream raw materials:

2-monochlorophenol

chloroacetonitrile

cyanomethyl bromide

Downstream raw materials:

2-(2-chloro-phenoxymethyl)-4,5-dihydro-1H-imidazole

5-(2-chloro-phenoxymethyl)-1H-tetrazole

2,2,2-Trichlor-1,1-bis-<(2-chlor-phenoxy)-acetamino>-aethan

Isonicotinic acid [1-amino-2-(2-chloro-phenoxy)-eth-(E)-ylidene]-hydrazide

Refernces

• 1、 Yu, Guanping,Kuo, David,Shoham, Menachem,Viswanathan, Rajesh. "Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa". supporting information. p. 85 - 91. Retrieved 2014/03/21.