4-Fluoro-4'-methoxybenzophenone

Base Information

• Chemical Name: 4-Fluoro-4'-methoxybenzophenone
• CAS No.: 345-89-1
• Molecular Formula: C14H11FO2
• Molecular Weight: 230.239
• Hs Code.: 2914700090
• European Community (EC) Number: 206-464-2
• DSSTox Substance ID: DTXSID10188060
• Nikkaji Number: J193.798G
• Wikidata: Q72474051
• Mol file: 345-89-1.mol

Synonyms:Benzophenone,4-fluoro-4'-methoxy- (6CI,8CI);(4-Fluorophenyl)(4-methoxyphenyl)methanone;4,4'-Fluoromethoxybenzophenone;p-(4-Fluorobenzoyl)anisole;

Chemical Property of 4-Fluoro-4'-methoxybenzophenone

Chemical Property:

• Appearance/Colour: White to off White Crystalline Powder
• Melting Point: 90-92 °C
• Boiling Point: 351.4 °C at 760 mmHg
• Flash Point: 160.7 °C
• PSA: 26.30000
• Density: 1.176 g/cm³
• LogP: 3.06530
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 230.07430775
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

99% ^*data from raw suppliers

(4-Fluorophenyl)(4-methoxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)F
• Uses: (4-Fluorophenyl)(4-methoxyphenyl)methanone

Technology Process of 4-Fluoro-4'-methoxybenzophenone

There total 55 articles about 4-Fluoro-4'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(p-fluorophenyl)(p-methoxyphenyl)methanol acetate → 4-fluoro-4'-methoxybenzophenone (345-89-1)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; chlorobenzene; at 130 ℃; for 2h;

Reference yield: 96.0%

1-(4-fluorobenzyl)-4-methoxybenzene (38695-26-0) → 4-fluoro-4'-methoxybenzophenone (345-89-1)

Guidance literature:

With tert.-butylnitrite; oxygen; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,1,2,2-tetrachloroethane; at 130 ℃; for 12h; Autoclave;

DOI:10.1016/j.tet.2015.07.042

Reference yield: 95.0%

(4-fluorophenyl)(4-methoxyphenyl)methanone oxime → 4-fluoro-4'-methoxybenzophenone (345-89-1)

Guidance literature:

With diphenyl ditelluride; oxygen; In ethyl acetate; for 24h; Irradiation;

DOI:10.1016/j.cclet.2020.09.012

upstream raw materials:

methoxybenzene

3-fluorobenzoyl chloride

methylene chloride

potassium salt of 4-fluoro-4'-hydroxybenzophenone

Downstream raw materials:

1-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-phenylethylene

1-(4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-yn-1-ol

(Z)-fluoro-clomiphene

fluoro-clomiphene

Refernces

• 1、 Trofimova, Alina,Holownia, Aleksandra,Tien, Chieh-Hung,?irvinskas, Martynas J.,Yudin, Andrei K.. "Acylboronates in polarity-reversed generation of acyl palladium(II) intermediates". supporting information. p. 3294 - 3299. Retrieved 2021/05/07.
• 2、 Idris, Muhammad Aliyu,Lee, Sunwoo. "Palladium-Catalyzed Amide N-C Hiyama Cross-Coupling: Synthesis of Ketones". supporting information. p. 9190 - 9195. Retrieved 2020/11/18.