4-Hydroxy-3,5-dimethoxybenzamide

Base Information

• Chemical Name: 4-Hydroxy-3,5-dimethoxybenzamide
• CAS No.: 3086-72-4
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.191
• Hs Code.: 2924299090
• European Community (EC) Number: 221-407-1
• NSC Number: 164893
• UNII: L8Y9YLN9U9
• DSSTox Substance ID: DTXSID3074573
• Nikkaji Number: J217.251H
• Wikidata: Q72483755
• Mol file: 3086-72-4.mol

Synonyms:4-Hydroxy-3,5-dimethoxybenzamide;3086-72-4;3,5-Dimethoxy-4-hydroxybenzamide;syringamide;Benzamide, 4-hydroxy-3,5-dimethoxy-;EINECS 221-407-1;Benzamide, 3,5-dimethoxy-4-hydroxy-;BRN 2649582;L8Y9YLN9U9;NSC-164893;NSC164893;UNII-L8Y9YLN9U9;SCHEMBL502534;DTXSID3074573;AKOS006281043;NSC 164893;LS-26567;FT-0730722

Chemical Property of 4-Hydroxy-3,5-dimethoxybenzamide

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0.000543mmHg at 25°C
• Melting Point: 184-185 °C(Solv: water (7732-18-5))
• Refractive Index: 1.566
• Boiling Point: 302.7 °C at 760 mmHg
• PKA: 8.67±0.23(Predicted)
• Flash Point: 136.9 °C
• PSA: 81.78000
• Density: 1.276 g/cm³
• LogP: 1.20860
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 197.06880783
• Heavy Atom Count: 14
• Complexity: 195

Purity/Quality:

99% ^*data from raw suppliers

SYRINGAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1O)OC)C(=O)N

Technology Process of 4-Hydroxy-3,5-dimethoxybenzamide

There total 2 articles about 4-Hydroxy-3,5-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,5-dimethoxy-4-hydroxybenzoic acid (530-57-4) → 4-hydroxy-3,5-dimethoxybenzamide (3086-72-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;

Reference yield:

→ 4-hydroxy-3,5-dimethoxybenzamide (3086-72-4)

Guidance literature:

aus Benzamid (II);

Reference yield: 84.0%

4-hydroxy-3,5-dimethoxybenzamide (3086-72-4) → 2,6-dimethoxy-p-quinone (530-55-2,26547-64-8)

Guidance literature:

With potassium nitrososulfonate; PO₄HNa₂-PO₄H₂Na; In chloroform;

DOI:10.1246/cl.1987.771

upstream raw materials:

3,5-dimethoxy-4-hydroxybenzoic acid

Downstream raw materials:

2,6-dimethoxy-p-quinone

Refernces