Basic information
- Name:
Pyridoxine hydrochloride
- CAS No.:
58-56-0
- Molecular Structure:
- Formula:
- C8H11NO3.ClH
- Molecular Weight:
- 205.64 .
- Synonyms:
- 3,4-Pyridinedimethanol,5-hydroxy-6-methyl-, hydrochloride (9CI);Pyridoxol, hydrochloride (7CI,8CI);2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride;4,5-Bis(hydroxymethyl)-2-methylpyridin-3-olhydrochloride;4,5-Bis(hydroxymethyl)-3-hydroxy-2-methylpyridine hydrochloride;5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride;Aderomine hydrochloride;Aderoxin;Aderoxine;Hexabetalin;Hexavibex;Pyridipca;Pyridox;Pyridoxin hydrochloride;Pyridoxine chloride;
- EINECS:
- 200-386-2
- Melting Point:
- 214-215 °C(lit.)
- Boiling Point:
- 491.9 °C at 760 mmHg
- Flash Point:
- 251.3 °C
- Solubility:
- 0.1 g/mL at 20 °C in water
- Appearance:
- Crystalline
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-37/39 Details
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Chemistry
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IUPAC Name: 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
Molecular Formula: C8H12ClNO3
Molecular Weight: 205.64 g/mol
SMILES: c1(c(cnc(c1O)C)CO)CO.Cl
InChI: InChI=1/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
EINECS: 200-386-2
Classification Code: Drug / Therapeutic Agent; Human Data; Mutation data; Reproductive Effect; Vitamin [enzyme co-factor]
Product Categories: Biochemistry; Pyridinium Compounds; Vitamins; Nutritional Supplements; Vitamins and derivatives; Aromatics; Heterocycles; Vitamin Ingredients
Flash Point: 251.3 °C
Enthalpy of Vaporization: 79.91 kJ/mol
Boiling Point: 491.9 °C at 760 mmHg
Melting Point: 214-215 °C(lit.)
storage temperature: 2-8 °C
solubility: H2O: 0.1 g/mL at 20 °C, clear, colorless
Sensitive: Light Sensitive
Stability: Stable. Protect from air and light.
Vapour Pressure of Pyridoxine hydrochloride (CAS NO.58-56-0): 1.71E-10 mmHg at 25 °C
Uses
Pyridoxine hydrochloride (CAS NO.58-56-0) is widely used in pharmaceutical ,food and feed additives and also could be used in the cosmetics .
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intramuscular | 500mg/kg (500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| cat | LD50 | intravenous | 560mg/kg (560mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| cat | LD50 | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| dog | LD50 | oral | > 500mg/kg (500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. | |
| mouse | LD50 | intravenous | 660mg/kg (660mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| mouse | LD50 | oral | 5500mg/kg (5500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| mouse | LD50 | subcutaneous | 2450mg/kg (2450mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| pigeon | LD50 | intravenous | 145mg/kg (145mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| rabbit | LD50 | intravenous | 464mg/kg (464mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| rat | LD50 | intravenous | 530mg/kg (530mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| rat | LD50 | oral | 4gm/kg (4000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
| rat | LD50 | subcutaneous | 3gm/kg (3000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS of Pyridoxine hydrochloride (CAS NO.58-56-0): UV1350000
Specification
Pyridoxine hydrochloride (CAS NO.58-56-0), its Synonyms are 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride ; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride ; Vitamin B6 hydrochloride ; 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride ; 3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride ; 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride ; 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride ; Aderomine hydrochloride ; 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1) . It is crystalline.