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Basic information

  • Name:

  • 1,2-Ethanediamine,N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-

  • CAS No.:

  • 91-84-9

  • Formula:
  • C17H23 N3 O
  • Synonyms:
  • 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl- (9CI);Pyridine,2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]- (7CI,8CI);2-[(2-Dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine;Afko-Hist;Anhistabs;Anhistol;Antalergan;Antallergan;Anthisan;Copsamine;Coradon;Dipane;Dorantamin;Harvamine;Histacap;Histasan;Isamin;Kriptin;Maranhist;Mepyramine;Mepyren;N-p-Methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine;NSC13136;Neo-Bridal;Neoantergan;Nyscaps;Pyra;Pyranisamine;Pyrilamine;RP2786;Statomin;Wait's green mountain antihistamine;

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Chemistry

Chemistry informtion about  Pyrilamine (CAS NO.91-84-9)  is:
IUPAC Name: N-[(4-methoxyphenyl)methyl]-N' , N'-dimethyl-N-pyridin-2-ylethane-1 , 2-diamine
Synonyms: 1,2-Ethanediamine , N-[(4-methoxyphenyl)methyl]-N' , N'-dimethyl-N-2-pyridinyl- ; 1,2-Ethanediamine , N-[(4-methoxyphenyl)methyl]-N' , N'-dimethyl-N-2-pyridyl- ; 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin ; 2-((2-(dimethylamino)ethyl)-(p-methoxybenzyl)amino)pyridine ; 2-((2-dimethylaminoethyl)(p-methoxybenzyl)amino)pyridine ; 2-((p-Methoxybenzyl)(2-(dimethylamino)ethyl)amino)pyridine ; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine ; Afko-Hist
MF: C17H23N3O
MW: 285.38
EINECS: 202-102-2 
Density: 1.088 g/cm3
Flash Point: 210.1 °C
Boiling Point: 423.8 °C at 760 mmHg
Vapour Pressure: 2.17E-07 mmHg at 25°C 
Enthalpy of Vaporization: 67.82 kJ/mol
Following is the molecular structure of  Pyrilamine (CAS NO.91-84-9)  is:

Uses

 Pyrilamine (CAS NO.91-84-9) is used as an antihistamine.

Toxicity Data With Reference

1.    

eye-rbt 1%

     OPHTAD    Ophtalmologica. 143 (1962),154.
2.    

eye-rbt 100 mg MLD

     FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
3.    

ims-rat TDLo:50 mg/kg (5D preg):REP

     PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 100 (1959),555.
4.    

ipr-rat TDLo:350 mg/kg (10-16D preg):TER

     JPHYA7    Journal of Physiology. 164 (1962),138.
5.    

unr-hmn TDLo:714 µg/kg:CNS

     JOALAS    Journal of Allergy, Including Allergy Abstracts. 19 (1948),313.
6.    

orl-mus LD50:220 mg/kg

     THERAP    Therapie. 26 (1971),1203.
7.    

ipr-mus LD50:107 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 25 (1975),1723.
8.    

scu-mus LD50:100 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 14 (8)(1964),940.
9.    

ivn-mus LD50:23 mg/kg

     THERAP    Therapie. 26 (1971),1203.

Safety Profile

Human poison by an unspecified route. An experimental poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Human systemic effects by unspecified route: sleep effects, somnolence and muscle contraction or spasticity. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.

Specification

General description about Pyrilamine (CAS NO.91-84-9), it is a viscous brown liquid.
Air & Water Reactions: May be sensitive to light. Insoluble in water.
Reactivity Profile: It neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
Health Hazard: Symptoms: Exposure to  Pyrilamine  may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.
Fire Hazard: Flash point data for it are not available; however, It is probably combustible.

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