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Name	Quazepam	EINECS	253-179-4
CAS No.	36735-22-5	Density	1.42 g/cm³
PSA	47.69000	LogP	4.52680
Solubility	N/A	Melting Point	22°C
Formula	C17H11 Cl F4 N2 S	Boiling Point	429.9 °C at 760 mmHg
Molecular Weight	386.8	Flash Point	213.8 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione;7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione;Doral; Dormalin; NSC 309702; Oniria; Prosedar; Quazepam; Quazium; Sch 16134;Selepam

Quazepam Synthetic route

: 36735-22-5
quazepam

: 49606-44-2
[3H]-2-Oxoquazepam

Conditions

Conditions	Yield
With Hg(CH3COO)2 at 20℃; for 0.25h; pH 11.2 (Britton-Robinson buffer); 40percent DMF as solubilisator;	100%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 10℃;	50%

: 68-11-1
mercaptoacetic acid

: 36735-22-5
quazepam

: 10-chloro-7,11b-dihydro-11b-(2-fluorophenyl)-7-(2,2,2-trifluoro-ethyl)-thiazolo<3,2-d><1,4>benzodiazepin-3(2H)one-6(5H)thione

Conditions

Conditions	Yield
In benzene for 45h; Heating;	42%

Quazepam Chemical Properties

IUPAC Name: 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
The MF of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is C₉H₆N₂S.

The MW of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is 174.22234.
Synonyms of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5): 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- ; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(2,2, 2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
Apperance: dichloromethane - hexane crystallization
Index of Refraction: 1.595
EINECS: 253-179-4
Density: 1.42 g/ml
Flash Point: 213.8 °C
Boiling Point: 429.9 °C
Melting Point: 137.5-139 °C

Quazepam Uses

2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is benzodiazepine class with a typical anti-anxiety, anti-seizure and muscle relaxant effect and low toxicity. Used for a variety of insomnia.

Quazepam Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	oral	> 1gm/kg (1000mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: ANALGESIA	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982.
dog	LD	oral	> 1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
mouse	LD50	intraperitoneal	845mg/kg (845mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
mouse	LDLo	oral	5gm/kg (5000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982.
rat	LD50	intraperitoneal	2749mg/kg (2749mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.

Quazepam Safety Profile

Safety information of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5):
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III

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