- Quinine
- Quinine benzoate
- Quinine dihydrochloride
- Quinine ethiodide
- Quinine ethylcarbonate
- Quinine formate
- Quinine gluconate
- Quinine hydrobromide
- Quinine hydrochloride
- Quinine hydrochloride dihydrate
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Cas Database |
| Name |
Quinine dihydrochloride |
EINECS | 200-493-4 |
| CAS No. | 60-93-5 | Density | N/A |
| PSA | 45.59000 | LogP | 4.71510 |
| Solubility | N/A | Melting Point |
238-2400C |
| Formula | C20H26Cl2N2O2 | Boiling Point | 495.9 °C at 760 mmHg |
| Molecular Weight | 360.884 | Flash Point | 253.7 °C |
| Transport Information | N/A | Appearance | white solid |
| Safety | 26-36 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Cinchonan-9-ol,6'-methoxy-, dihydrochloride, (8a,9R)- (9CI);Quinine, dihydrochloride (8CI);(-)-Quinine dihydrochloride;Acid quinine hydrochloride;Quinine bimuriate;Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:2), (8a,9R)-; |
Article Data | 3 |
Quinine dihydrochloride Chemical Properties
Molecular structure of Quinine dihydrochloride (CAS NO.60-93-5) is:
Molecular Weight: 397.33864 [g/mol]
Molecular Formula: C20H26Cl2N2O2
Product Name: Quinine dihydrochloride
CAS Registry Number: 60-93-5
IUPAC Name: (R)-[(4S,5R,7S)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol dihydrochloride
H-Bond Donor: 3
H-Bond Acceptor: 4
EINECS: 200-493-4
Melting Point: 238-2400 °C
Flash Point: 253.7 °C
Enthalpy of Vaporization: 80.41 kJ/mol
Boiling Point: 495.9 °C at 760 mmHg
Vapour Pressure: 1.19E-10 mmHg at 25°C
Stability: Stable, but may be light sensitive. Efflorescent. Incompatible with strong oxidizing agents.
Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Quinine dihydrochloride Uses
Quinine dihydrochloride (CAS NO.60-93-5) is an alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633.
Quinine dihydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 630mg/kg/1W-I (630mg/kg) | SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE GASTROINTESTINAL: NAUSEA OR VOMITING | Japanese Journal of Ophthalmology. Vol. 28, Pg. 409, 1984. |
| guinea pig | LD50 | intravenous | 57mg/kg (57mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| guinea pig | LDLo | subcutaneous | 199mg/kg (199mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 32, Pg. 595, 1935. | |
| mouse | LD50 | intravenous | 86mg/kg (86mg/kg) | Biochemical Journal. Vol. 28, Pg. 426, 1934. | |
| mouse | LD50 | oral | 660mg/kg (660mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. | |
| rabbit | LD50 | intravenous | 35mg/kg (35mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rabbit | LD50 | oral | 641mg/kg (641mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. | |
| rat | LD50 | intravenous | 78mg/kg (78mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rat | LD50 | oral | 1392mg/kg (1392mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
Quinine dihydrochloride Safety Profile
Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Safety Information of Quinine dihydrochloride (CAS NO.60-93-5) is:
Hazard Codes: Xi.gif){kind=small}
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36: Wear suitable protective clothing
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
Quinine dihydrochloride Specification
Quinine dihydrochloride , its cas register number is 60-93-5. It also can be called (-)-Quinine dihydrochloride ; Acid quinine hydrochloride ; Chinindihydrochlorid ; Quinine HCl ; Cinchonan-9-ol, 6'-methoxy-, dihydrochloride, (8-alpha,9R) (9CI) ; (6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol dihydrochloride .It is a white solid.
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