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Toxicity Data With Reference

1.   

orl-rat LD50:6500 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),916.
2.   

ipr-rat LD50:2250 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 5 (1977),943.
3.   

orl-mus LD50:4400 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 5 (1977),943.
4.   

ipr-mus LD50:2500 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 5 (1977),943.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects.

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