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Basic information

  • Name:

  • Rebamipide

  • CAS No.:

  • 90098-04-7

  • Formula:
  • C19H15ClN2O4
  • Synonyms:
  • Mucosta;OPC 12759;Proamipide;Itopride Hydrochloride;

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Chemistry

Structure of Rebamipide (CAS NO.90098-04-7):

IUPAC Name: 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid 
Empirical Formula: C19H15ClN2O4
Molecular Weight: 370.7864 
Index of Refraction: 1.634
Molar Refractivity: 95.07 cm3
Molar Volume: 265.8 cm3
Polarizability: 37.69×10-24cm3
Surface Tension: 58.3 dyne/cm
Density: 1.394 g/cm3
Flash Point: 374.1 °C
Enthalpy of Vaporization: 106.9 kJ/mol 
Melting Point: 288-290°C dec.
Boiling Point: 695 °C at 760 mmHg
Vapour Pressure: 2.83E-20 mmHg at 25°C 
Physical Appearance: White Powder
Product Categories: Amino Acid Derivatives;Active Pharmaceutical Ingredients;Antiulcerative;Intermediates & Fine Chemicals;Pharmaceuticals;API's

Uses

Shows antiulcer activity in rats.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LD50 intramuscular 1353mg/kg (1353mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BLOOD: CHANGES IN SPLEEN		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LD50 intravenous 572mg/kg (572mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: OTHER CHANGES		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LD50 subcutaneous 2637mg/kg (2637mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LDLo oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rabbit LD50 oral > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LD50 intravenous 700mg/kg (700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LDLo intramuscular 1gm/kg (1000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LDLo oral 5gm/kg (5000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LDLo subcutaneous 4gm/kg (4000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.

Specification

  Rebamipide , its cas register number is 90098-04-7. It also can be called (+-)-2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid ; Mucosta ; Proamipide .

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