Basic information
- Name:
Ribostamycin sulfate
- CAS No.:
53797-35-6
- Molecular Structure:
- Formula:
- C17H34N4O10.H2SO4
- Molecular Weight:
- 552.55
- Synonyms:
- Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;Vistamycin (TN);Ribomycine;5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[(2S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;SF 733 antibioic sulfate;Ribostamin;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol sulfate;Ribostamycin sulfate salt;Prestwick_190;Ribostamycin sulfate (JP14);Ribostamycin sulphate;Riboflavine sulfate;Landamycine;GA4+7;
- EINECS:
- 258-783-1
- Boiling Point:
- 907.6 °C at 760 mmHg
- Flash Point:
- 502.7 °C
- Hazard Symbols:
T,
Xi- Risk Codes:
- 61-20/21/22-36/38
- Safety Description:
- 53-22-36/37/39-45-26 Details
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Chemistry
Molecular Formula: C17H34N4O10.H2SO4
Molar mass: 552.55 g/mol
EINECS: 258-783-1
Flash Point: 502.7 °C
Boiling Point: 907.6 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Melting point: 175-180°C
Storage temp: 2-8°C
Product categories of Ribostamycin sulfate (53797-35-6): Antibacterial;Interferes with Protein SynthesisSpectrum of Activity;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;Mechanism of Action
Structure of Ribostamycin sulfate (53797-35-6):
H-Bond Donor: 12
H-Bond Acceptor: 18
Systematic Name: (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2R,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol; sulfuric acid
SMILES: OS(O)(=O)=O.O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3O[C@H]2[C@H](O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N)[C@@H](N)C[C@@H](N)C2O
InChI: InChI=1/C17H34N4O10.H2O4S/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17;1-5(2,3)4/h4-17,22-27H,1-3,18-21H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8-,9?,10-,11-,12-,13-,14-,15-,16-,17+;/m1./s1
InChIKey: RTCDDYYZMGGHOE-BJRDGYLYBV
Std. InChI: InChI=1S/C17H34N4O10.H2O4S/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17;1-5(2,3)4/h4-17,22-27H,1-3,18-21H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8-,9?,10-,11-,12-,13-,14-,15-,16-,17+;/m1./s1
Std. InChIKey: RTCDDYYZMGGHOE-BJRDGYLYSA-N
Uses
Ribostamycin sulfate (53797-35-6) can be used for bronchitis, pneumonia, pleurisy, lymphadenitis, cholecystitis, Boil, osteomyelitis, urinary tract infection treatment caused by the susceptible strains.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 1561mg/kg (1561mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973. | |
| mouse | LD50 | intraperitoneal | 1981mg/kg (1981mg/kg) | Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973. | |
| mouse | LD50 | intravenous | 210mg/kg (210mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973. | |
| mouse | LD50 | oral | > 7gm/kg (7000mg/kg) | Drugs in Japan Vol. 6, Pg. 885, 1982. | |
| mouse | LD50 | subcutaneous | 2345mg/kg (2345mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973. | |
| rat | LD50 | intramuscular | 2030mg/kg (2030mg/kg) | Drugs in Japan Vol. 6, Pg. 885, 1982. | |
| rat | LD50 | intraperitoneal | 3080mg/kg (3080mg/kg) | Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973. | |
| rat | LD50 | intravenous | 375mg/kg (375mg/kg) | Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973. | |
| rat | LD50 | oral | > 7gm/kg (7000mg/kg) | Drugs in Japan Vol. 6, Pg. 885, 1982. | |
| rat | LD50 | subcutaneous | 5600mg/kg (5600mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973. |
Safety Profile
Poison by intravenous route. Moderately toxic by intraperitoneal, intramuscular, and subcutaneous routes. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Hazard Codes: T.gif){kind=small}
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Risk Statements:
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
38: Irritating to the skin
61: May cause harm to the unborn child
Safety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
Specification
Ribostamycin sulfate (53797-35-6) also can be called Ribostamycin ; Ribostamin and Landamycine .