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Basic information

  • Name:
  • Rifabutin

  • CAS No.:
  • 72559-06-9

  • Formula:
  • C46H62N4O11
  • Synonyms:
  • Rifubutine;Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)- 2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'- piperidine]-5,10,26(3H,9H)-trione,16- (acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,- 9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-,(9S,12E,14S,15R,16S,17R,18R,19R,- 20S,21S,22E,24Z)-;LM 427;Mycobutin;4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S;Antibiotic LM 427;AZT & Ansamycin;Rifabutine;RBT;Thymidine, 3-azido-3-deoxy- & Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2,3:7,8]naphth[1,2-d]imidazole-2,4-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-;Ansatipine;RBU;Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2,3:7,8]naphth[1,2-d]imidazole-2,4-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-;3-Azido-3-deoxythymidine & Ansamycin;Alfacid;Assatipin;LM427;Ansamycin;Rifabutin (USP);Mycobutin (TN);
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Chemistry

Rifabutin's molecular formula is C46H62N4O11 and its molecular weight is 847.

History

Scientists at the Italian drug company Achifar discovered rifabutin in 1975. Eventually Archifar became part of Farmitalia Carlo Erba, a unit of the conglomerate Montedison. This company's Adria Laboratories subsidiary filed for Food and Drug Administration (FDA) approval of rifabutin under the brand name Mycobutin in the early 1990s and the drug gained FDA approval in December 1992.

Uses

1、Rifabutin is used in the treatment of mycobacterium avium complex disease, a bacterial infection most commonly encountered in late-stage AIDS patients.
2、Rifabutin is well tolerated in patients with HIV-related tuberculosis (TB).
3、Rifabutin is also used in trials for treating Crohn's Disease as part of the anti-MAP therapy. It has shown significant improvement of the condition in some patients.

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